Direct Copper-Catalyzed C-H Monofluoroalkylation of Benzoxazoles with 1-Fluoro-1-haloalkanes

Wei Li, Andrii Varenikov, Mark Gandelman

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The first example of direct C–H bond monofluoroalkylation with 1-fluoro-1-haloalkanes with no adjacent functional groups and with β-hydrogens has been developed. This transformation offers a straightforward route for the synthesis of a series of monofluoroalkylated benzoxazoles.

Original languageEnglish
Pages (from-to)3138-3141
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number21
StatePublished - 8 Jun 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim


Supported by a Technion-Guangdong Fellowship, and by Israeli Science Foundation, Grant 1449/19.

FundersFunder number
Israeli Science Foundation1449/19


    • Benzoxazoles
    • Copper
    • Cross-coupling
    • C–H activation
    • Secondary alkyl fluorides


    Dive into the research topics of 'Direct Copper-Catalyzed C-H Monofluoroalkylation of Benzoxazoles with 1-Fluoro-1-haloalkanes'. Together they form a unique fingerprint.

    Cite this