Abstract
The first example of direct C–H bond monofluoroalkylation with 1-fluoro-1-haloalkanes with no adjacent functional groups and with β-hydrogens has been developed. This transformation offers a straightforward route for the synthesis of a series of monofluoroalkylated benzoxazoles.
Original language | English |
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Pages (from-to) | 3138-3141 |
Number of pages | 4 |
Journal | European Journal of Organic Chemistry |
Volume | 2020 |
Issue number | 21 |
DOIs | |
State | Published - 8 Jun 2020 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Funding
Supported by a Technion-Guangdong Fellowship, and by Israeli Science Foundation, Grant 1449/19.
Funders | Funder number |
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Israeli Science Foundation | 1449/19 |
Technion-Guangdong |
Keywords
- Benzoxazoles
- Copper
- Cross-coupling
- C–H activation
- Secondary alkyl fluorides