Direct Copper-Catalyzed C-H Monofluoroalkylation of Benzoxazoles with 1-Fluoro-1-haloalkanes

Wei Li, Andrii Varenikov, Mark Gandelman

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The first example of direct C–H bond monofluoroalkylation with 1-fluoro-1-haloalkanes with no adjacent functional groups and with β-hydrogens has been developed. This transformation offers a straightforward route for the synthesis of a series of monofluoroalkylated benzoxazoles.

Original languageEnglish
Pages (from-to)3138-3141
Number of pages4
JournalEuropean Journal of Organic Chemistry
Volume2020
Issue number21
DOIs
StatePublished - 8 Jun 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Funding

Supported by a Technion-Guangdong Fellowship, and by Israeli Science Foundation, Grant 1449/19.

FundersFunder number
Israeli Science Foundation1449/19
Technion-Guangdong

    Keywords

    • Benzoxazoles
    • Copper
    • Cross-coupling
    • C–H activation
    • Secondary alkyl fluorides

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