Dinucleoside poly(borano)phosphate derivatives and uses thereof

The present invention provides dinucleoside boranophosphate derivatives of the general formula I: Figure US07368439-20080506-C00001 wherein X and X′ each independently is an unsubstituted or substituted purine or pyrimidine residue; Y and Y′ each independently is H or OH; Z1 to Z5 each independently is O− or BH3 −, but excluding the compounds wherein Z1 to Z5 are each O−; W1 to W4 each independently is O, CH2, NH or C(Halogen)2; n and n′ each independently is 0 or 1; m is 3, 4 or 5; and M+ represents a pharmaceutically acceptable cation, and to pharmaceutical compositions thereof. These dinucleoside boranophosphates are useful for prevention or treatment of diseases or disorders modulated by P2Y receptors such as type 2 diabetes, cystic fibrosis and cancer.