Dilactams. Synthesis of nonsymmetrical dibenzodiazocinediones

Alfred Hassner, Bin Sun, Gary Gellermann, Simcha Meir

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


We report the first examples of nonsymmetrical dibenzodiazocinediones, mono-, di-, tri- and tetra-substituted in the aromatic rings including a benzo pyridino diazocine, by a new short method without the requirement of protection. The procedure involves conversion of an anthranilic acid to its sulfinamide lactone followed by direct heating with a different N-alkylanthranilic acid.

Original languageEnglish
Pages (from-to)1377-1379
Number of pages3
JournalTetrahedron Letters
Issue number7
StatePublished - 9 Feb 2004

Bibliographical note

Funding Information:
Support of this research by Compugen Ltd. and by the Marcus Center for Medicinal and Pharmaceutical Chemistry at Bar-Ilan University is gratefully acknowledged.


  • Anthranilic acids
  • Diazocine
  • Dibenzodiazocine
  • Dilactam synthesis
  • Eight-membered ring


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