Dilactams. Synthesis of nonsymmetrical dibenzodiazocinediones

Alfred Hassner; Bin Sun; Gary Gellermann; Simcha Meir

doi:10.1016/j.tetlet.2003.12.079

Dilactams. Synthesis of nonsymmetrical dibenzodiazocinediones

Alfred Hassner, Bin Sun, Gary Gellermann, Simcha Meir

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We report the first examples of nonsymmetrical dibenzodiazocinediones, mono-, di-, tri- and tetra-substituted in the aromatic rings including a benzo pyridino diazocine, by a new short method without the requirement of protection. The procedure involves conversion of an anthranilic acid to its sulfinamide lactone followed by direct heating with a different N-alkylanthranilic acid.

Original language	English
Pages (from-to)	1377-1379
Number of pages	3
Journal	Tetrahedron Letters
Volume	45
Issue number	7
DOIs	https://doi.org/10.1016/j.tetlet.2003.12.079
State	Published - 9 Feb 2004

Bibliographical note

Funding Information:
Support of this research by Compugen Ltd. and by the Marcus Center for Medicinal and Pharmaceutical Chemistry at Bar-Ilan University is gratefully acknowledged.

Keywords

Anthranilic acids
Diazocine
Dibenzodiazocine
Dilactam synthesis
Eight-membered ring

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10.1016/j.tetlet.2003.12.079

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abstract = "We report the first examples of nonsymmetrical dibenzodiazocinediones, mono-, di-, tri- and tetra-substituted in the aromatic rings including a benzo pyridino diazocine, by a new short method without the requirement of protection. The procedure involves conversion of an anthranilic acid to its sulfinamide lactone followed by direct heating with a different N-alkylanthranilic acid.",

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author = "Alfred Hassner and Bin Sun and Gary Gellermann and Simcha Meir",

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AU - Hassner, Alfred

AU - Sun, Bin

AU - Gellermann, Gary

AU - Meir, Simcha

N1 - Funding Information: Support of this research by Compugen Ltd. and by the Marcus Center for Medicinal and Pharmaceutical Chemistry at Bar-Ilan University is gratefully acknowledged.

PY - 2004/2/9

Y1 - 2004/2/9

N2 - We report the first examples of nonsymmetrical dibenzodiazocinediones, mono-, di-, tri- and tetra-substituted in the aromatic rings including a benzo pyridino diazocine, by a new short method without the requirement of protection. The procedure involves conversion of an anthranilic acid to its sulfinamide lactone followed by direct heating with a different N-alkylanthranilic acid.

AB - We report the first examples of nonsymmetrical dibenzodiazocinediones, mono-, di-, tri- and tetra-substituted in the aromatic rings including a benzo pyridino diazocine, by a new short method without the requirement of protection. The procedure involves conversion of an anthranilic acid to its sulfinamide lactone followed by direct heating with a different N-alkylanthranilic acid.

KW - Anthranilic acids

KW - Diazocine

KW - Dibenzodiazocine

KW - Dilactam synthesis

KW - Eight-membered ring

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 7

ER -

Dilactams. Synthesis of nonsymmetrical dibenzodiazocinediones

Abstract

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Keywords

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