Diffusion of peptides through hydrogel membranes

Abraham Domb, G. W.Raymond Davidson, Lynda M. Sanders

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Diffusion of four decapeptides (LHRH analogs) through glycerol methacrylate, hydroxyethyl methacrylate, and hydroxyethyl methacrylate-co-methyl methacrylate hydrogels was studied, and the results compared with theory. Polymer films were prepared both by film casting from a monomer solution and by in situ polymerization. For membranes with high water content (≥ 31% w/w), permeability was found to vary exponentially with the reciprocal of the degree of hydration of the membrane, as predicted by an analysis based on free volume theory.

Original languageEnglish
Pages (from-to)133-144
Number of pages12
JournalJournal of Controlled Release
Issue number2
StatePublished - Oct 1990
Externally publishedYes


  • hydration
  • hydrogel membranes
  • luteinizing hormone releasing hormone
  • nafaralin
  • poly(hydroxyalkyl methacrylate)


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