Diffusion of four decapeptides (LHRH analogs) through glycerol methacrylate, hydroxyethyl methacrylate, and hydroxyethyl methacrylate-co-methyl methacrylate hydrogels was studied, and the results compared with theory. Polymer films were prepared both by film casting from a monomer solution and by in situ polymerization. For membranes with high water content (≥ 31% w/w), permeability was found to vary exponentially with the reciprocal of the degree of hydration of the membrane, as predicted by an analysis based on free volume theory.
- hydrogel membranes
- luteinizing hormone releasing hormone
- poly(hydroxyalkyl methacrylate)