TY - JOUR
T1 - Diffusion of peptides through hydrogel membranes
AU - Domb, Abraham
AU - Davidson, G. W.Raymond
AU - Sanders, Lynda M.
PY - 1990/10
Y1 - 1990/10
N2 - Diffusion of four decapeptides (LHRH analogs) through glycerol methacrylate, hydroxyethyl methacrylate, and hydroxyethyl methacrylate-co-methyl methacrylate hydrogels was studied, and the results compared with theory. Polymer films were prepared both by film casting from a monomer solution and by in situ polymerization. For membranes with high water content (≥ 31% w/w), permeability was found to vary exponentially with the reciprocal of the degree of hydration of the membrane, as predicted by an analysis based on free volume theory.
AB - Diffusion of four decapeptides (LHRH analogs) through glycerol methacrylate, hydroxyethyl methacrylate, and hydroxyethyl methacrylate-co-methyl methacrylate hydrogels was studied, and the results compared with theory. Polymer films were prepared both by film casting from a monomer solution and by in situ polymerization. For membranes with high water content (≥ 31% w/w), permeability was found to vary exponentially with the reciprocal of the degree of hydration of the membrane, as predicted by an analysis based on free volume theory.
KW - hydration
KW - hydrogel membranes
KW - luteinizing hormone releasing hormone
KW - nafaralin
KW - poly(hydroxyalkyl methacrylate)
UR - http://www.scopus.com/inward/record.url?scp=0025096443&partnerID=8YFLogxK
U2 - 10.1016/0168-3659(90)90150-r
DO - 10.1016/0168-3659(90)90150-r
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AN - SCOPUS:0025096443
SN - 0168-3659
VL - 14
SP - 133
EP - 144
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 2
ER -