TY - JOUR
T1 - Differentiating Serine and Cysteine Protease Mechanisms by New Covalent QSAR Descriptors
AU - Shokhen, Michael
AU - Traube, Tamar
AU - Vijayakumar, Subramaniam
AU - Hirsch, Michal
AU - Uritsky, Neta
AU - Albeck, Amnon
PY - 2011/5/2
Y1 - 2011/5/2
N2 - QSAR-A mechanistic tool for proteases: New covalent QSAR descriptors for enzyme inhibition, W1 and W2, serve as mechanistic tools in the study of Ser and Cys proteases, providing support to an ionic tetrahedral complex for the former and a neutral (protonated) tetrahedral complex for the latter.
AB - QSAR-A mechanistic tool for proteases: New covalent QSAR descriptors for enzyme inhibition, W1 and W2, serve as mechanistic tools in the study of Ser and Cys proteases, providing support to an ionic tetrahedral complex for the former and a neutral (protonated) tetrahedral complex for the latter.
KW - Alpha-ketoheteroaromatics
KW - Covalent inhibitors
KW - Enzyme mechanism
KW - Molecular modeling
KW - Structure-activity relationships
UR - http://www.scopus.com/inward/record.url?scp=79955023443&partnerID=8YFLogxK
U2 - 10.1002/cbic.201000459
DO - 10.1002/cbic.201000459
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 21438106
AN - SCOPUS:79955023443
SN - 1439-4227
VL - 12
SP - 1023
EP - 1026
JO - ChemBioChem
JF - ChemBioChem
IS - 7
ER -