Differential regulation of neurotrophin expression by mitogens and neurotransmitters in mouse lymphocytes

Rina Barouch, Elena Appel, Gila Kazimirsky, Armin Braun, Harald Renz, Chaya Brodie

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78 Scopus citations


In this study, we examined the expression of neurotrophins in mouse lymphocytes and the regulation of their expression by mitogens and neurotransmitters. We found that mixed splenocytes as well as T and B lymphocytes expressed mRNA for all the neurotrophins examined. Differential regulation of the neurotrophins was obtained upon stimulation of the cells. Thus, LPS increased the expression of NGF, BDNF and NT-3 in splenocytes and B cells, whereas Con-A increased the mRNA of NT-3 and NT-4 in T cells and NGF expression in splenocytes. The neurotransmitter substance P and the β-adrenergic agonist, isoproterenol induced an increase in the expression of NGF. Our results suggest an important role for the different neurotrophins in the function of the immune system and point to a bi-directional interaction between neurotrophins and neurotransmitters in this system. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)112-121
Number of pages10
JournalJournal of Neuroimmunology
Issue number2
StatePublished - 1 Mar 2000

Bibliographical note

Funding Information:
This work was supported by the Volkswagen-Stiftung Foundation.


  • Immune system
  • Lymphocytes
  • Mitogens
  • Neurotransmitters
  • Neurotrophins


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