Abstract
Sindbis virus is an alphavirus that infects cells in either lytic or persistent infection. In this study we examined the effects of Sindbis virus on cell apoptosis and on the expression of Bcl-2 and Bax. Of the two strains studied, SVA and SVNI, only the neurovirulent strain, SVNI, induced apoptosis of astrocytes and PC-12 cells. SVA, which infects cells in a persistent manner, induced up-regulation of bcl-2 mRNA and Bcl-2 protein, whereas SVNI induced an increase in Bax levels. Our results indicate a differential regulation of Bcl2 and Bax expression by SVA and SVNI, which may be associated with the apoptotic potential of the viruses. (C) 2000 Academic Press.
Original language | English |
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Pages (from-to) | 238-242 |
Number of pages | 5 |
Journal | Virology |
Volume | 276 |
Issue number | 2 |
DOIs | |
State | Published - 25 Oct 2000 |
Bibliographical note
Funding Information:We thank Dr. Ronit Sarid for helpful discussions. This work was supported by Israel Science Foundation Grant 72696-16.6.
Funding
We thank Dr. Ronit Sarid for helpful discussions. This work was supported by Israel Science Foundation Grant 72696-16.6.
Funders | Funder number |
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Israel Science Foundation | 72696-16.6 |