Differential regulation of Bcl-2 and bax expression in cells infected with virulent and nonvirulent strains of Sindbis virus

Elena Appel, Ayelet Katzoff, Tehila Ben-Moshe, Gila Kazimirsky, David Kobiler, Shlomo Lustig, Chaya Brodie

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Sindbis virus is an alphavirus that infects cells in either lytic or persistent infection. In this study we examined the effects of Sindbis virus on cell apoptosis and on the expression of Bcl-2 and Bax. Of the two strains studied, SVA and SVNI, only the neurovirulent strain, SVNI, induced apoptosis of astrocytes and PC-12 cells. SVA, which infects cells in a persistent manner, induced up-regulation of bcl-2 mRNA and Bcl-2 protein, whereas SVNI induced an increase in Bax levels. Our results indicate a differential regulation of Bcl2 and Bax expression by SVA and SVNI, which may be associated with the apoptotic potential of the viruses. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)238-242
Number of pages5
JournalVirology
Volume276
Issue number2
DOIs
StatePublished - 25 Oct 2000

Bibliographical note

Funding Information:
We thank Dr. Ronit Sarid for helpful discussions. This work was supported by Israel Science Foundation Grant 72696-16.6.

Funding

We thank Dr. Ronit Sarid for helpful discussions. This work was supported by Israel Science Foundation Grant 72696-16.6.

FundersFunder number
Israel Science Foundation72696-16.6

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