Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells

Keyphrases

• Human Embryonic Stem Cells (hESCs) 100%
• Induced Pluripotent Stem Cells (iPSCs) 100%
• Fragile X Syndrome 100%
• Differential Modeling 100%
• Fragile X Mental Retardation 1 (FMR1) 88%
• Embryonic Stem Cells 44%
• Fibroblasts 33%
• Stem Cell Lines 22%
• Somatic Cells 22%
• Cell Clones 16%
• Pluripotency 16%
• Pluripotent Stem Cells 16%
• Preimplantation Genetic Diagnosis 16%
• Human Development 11%
• Immunostaining 11%
• Stem Cell-derived 11%
• Transcriptional Repression 11%
• Germ Layers 11%
• Specific mutation 11%
• Histone Modification 11%
• Pluripotent Cells 11%
• Lung Fibroblasts 11%
• Human Pluripotent Stem Cells (hPSCs) 11%
• TRA-1-60 11%
• Gene Expression 5%
• Genetic mutation 5%
• Developmental Processes 5%
• Hierarchical Clustering 5%
• Fetus 5%
• Quantitative PCR 5%
• Intellectual Disability 5%
• DNA Microarray 5%
• Cell Differentiation 5%
• Disease Phenotype 5%
• Gene Silencing 5%
• Clinical Application 5%
• Mesoderm 5%
• Sex-determining Region Y-box 2 (SOX2) 5%
• Deacetylation 5%
• Most Common Form 5%
• 3′-untranslated Region (3′-UTR) 5%
• Disease-specific 5%
• Lung 5%
• Alkaline Phosphatase 5%
• Early Events 5%
• Cell Clusters 5%
• MRC-5 5%
• Skin Fibroblasts 5%
• DNA Methylation (DNAm) 5%
• Older Individuals 5%
• Blastocyst 5%
• Human Genetic Disorders 5%
• Plot Analysis 5%
• DNA Methylation Age 5%
• Nanog 5%
• Octamer-binding Transcription Factor 4 (OCT4) 5%
• Embryoid Body 5%
• Repeat Region 5%
• Cell of Origin 5%
• Undifferentiated Cells 5%
• Human Embryo 5%
• Teratoma 5%
• Scatterplot 5%
• Triplet Repeat Expansion 5%
• Sample Support 5%
• Gene mutagenesis 5%
• H3K4 Methylation 5%
• Fetal Lung 5%
• CGG Repeat 5%
• Heterochromatin 5%
• Hypermethylation 5%
• Histone H3 Tail 5%
• SSEA-4 5%
• 2C-I 5%
• Endoderm 5%
• Tissue Source 5%
• Stem Cell Morphology 5%
• Triplet Repeats 5%
• Defined Factors 5%
• Diploid Karyotype 5%
• H3K9 Methylation 5%
• Embryonic Stem Cell Differentiation 5%
• Chorionic Villus Sampling 5%
• Human Embryonic Stem Cell Lines 5%
• Ectoderm 5%
• Chromatin Modification 5%
• Critical Difference 5%
• Histone H3K4 5%
• Typical Characteristics 5%
• SSEA-3 5%
• High Passage 5%
• Four-year-olds 5%

Biochemistry, Genetics and Molecular Biology

• Embryonic Stem Cell 100%
• Induced Pluripotent Stem Cell 100%
• Fibroblast 50%
• Stem Cell 27%
• Stem Cell Line 27%
• Reprogramming 22%
• Somatic Cell 22%
• Preimplantation Genetic Diagnosis 16%
• Cell Clone 16%
• Transcription 11%
• Wild Type 11%
• Immunostaining 11%
• Histone 11%
• Histone Modification 11%
• Cellular Differentiation 11%
• DNA Methylation 11%
• Human Development 11%
• Germ Layer 11%
• Methylation 5%
• Animal Model 5%
• Mutagenesis 5%
• Gene Silencing 5%
• Transgene 5%
• Demethylation 5%
• DNA Microarray 5%
• Reverse Transcription Polymerase Chain Reaction 5%
• Karyotype 5%
• Ectoderm 5%
• Gene Expression 5%
• Promoter Region 5%
• Gene Mutation 5%
• Deacetylation 5%
• Untranslated Region 5%
• Blastocyst 5%
• Human Genetic Disorder 5%
• Diploidy 5%
• Embryoid Body 5%
• Chorion Villus 5%
• SOX2 5%
• Heterochromatin 5%
• Mesoderm 5%
• Alkaline Phosphatase 5%
• Endoderm 5%
• Histone H3 5%
• Epiblast 5%
• Teratoma 5%

Neuroscience

• Stem Cell 100%
• Embryonic Stem Cell 100%
• Fragile X Syndrome 100%
• Fibroblast 39%
• Cell Line 21%
• Reprogramming 17%
• Somatic Cell 17%
• Cellular Differentiation 8%
• DNA Methylation 8%
• Histone Modification 8%
• Histone 8%
• Epileptic Absence 8%
• Immunohistochemistry 8%
• In Vivo 4%
• Methylation 4%
• Alkaline Phosphatase 4%
• Mutagenesis 4%
• Histone H3 4%
• Untranslated Region 4%
• SOX2 4%
• Heterochromatin 4%
• Gene Expression 4%
• Promoter Region 4%
• Gene Mutation 4%
• Blastocyst 4%
• Diploidy 4%
• Embryoid Body 4%
• Chorion Villus 4%
• Gene Silencing 4%
• Mesoderm 4%
• DNA Microarray 4%
• Transgene 4%
• Endoderm 4%
• Karyotype 4%
• Epiblast 4%