Differential expression of Islet-1 in neural crest-derived ganglia: Islet-1 + dorsal root ganglion cells are post-mitotic and Islet-1 + sympathetic ganglion cells are still cycling

Camila Avivi; Ronald S. Goldstein

doi:10.1016/S0165-3806(99)00054-1

Differential expression of Islet-1 in neural crest-derived ganglia: Islet-1 + dorsal root ganglion cells are post-mitotic and Islet-1 + sympathetic ganglion cells are still cycling

Camila Avivi, Ronald S. Goldstein

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The Islet-1 antigen is an early marker of differentiation of neural tube cells, and is expressed in many other embryonic cells as well. It had been reported that Islet-1 is expressed only in post-mitotic sympathetic neuroblasts in vitro, unlike other differentiation markers. We have double- labeled St. 23 chick embryos for bromodeoxyuridine (BrDU) and Islet-1 and found that neural tube and dorsal root ganglion (DRG) cells express Islet-1 after leaving the cell cycle, while sympathetic ganglion (SG) cells express Islet-1 while still dividing.

Original language	English
Pages (from-to)	89-92
Number of pages	4
Journal	Developmental Brain Research
Volume	115
Issue number	1
DOIs	https://doi.org/10.1016/S0165-3806(99)00054-1
State	Published - 8 Jun 1999

Bibliographical note

Funding Information:
Thanks are due to Dr. Benny Motro for his critical reading of the manuscript and Dr. Leonid Roitman for help with confocal microscopy. This work was supported by grants from the Dysautonomia Foundation, the Israel Institute for Psychobiology, Charles Smith Foundation and the Health Science Center at Bar-Ilan University, The Aviv Fund for Neuroscience Research. Monoclonal antibodies 40.2D6 (Islet-1) and 4F2 (Lim 2) were developed by T. Jessell and obtained from the Developmental Studies Hybridoma Bank developed under the auspices of the NICHD and maintained by the University of Iowa, Department of Biological Sciences, Iowa City, IA, 52242.

Keywords

Differentiation marker
Dorsal root ganglia
Islet-1
Neural crest
Proliferation
Sympathetic ganglion

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abstract = "The Islet-1 antigen is an early marker of differentiation of neural tube cells, and is expressed in many other embryonic cells as well. It had been reported that Islet-1 is expressed only in post-mitotic sympathetic neuroblasts in vitro, unlike other differentiation markers. We have double- labeled St. 23 chick embryos for bromodeoxyuridine (BrDU) and Islet-1 and found that neural tube and dorsal root ganglion (DRG) cells express Islet-1 after leaving the cell cycle, while sympathetic ganglion (SG) cells express Islet-1 while still dividing.",

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note = "Funding Information: Thanks are due to Dr. Benny Motro for his critical reading of the manuscript and Dr. Leonid Roitman for help with confocal microscopy. This work was supported by grants from the Dysautonomia Foundation, the Israel Institute for Psychobiology, Charles Smith Foundation and the Health Science Center at Bar-Ilan University, The Aviv Fund for Neuroscience Research. Monoclonal antibodies 40.2D6 (Islet-1) and 4F2 (Lim 2) were developed by T. Jessell and obtained from the Developmental Studies Hybridoma Bank developed under the auspices of the NICHD and maintained by the University of Iowa, Department of Biological Sciences, Iowa City, IA, 52242.",

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AB - The Islet-1 antigen is an early marker of differentiation of neural tube cells, and is expressed in many other embryonic cells as well. It had been reported that Islet-1 is expressed only in post-mitotic sympathetic neuroblasts in vitro, unlike other differentiation markers. We have double- labeled St. 23 chick embryos for bromodeoxyuridine (BrDU) and Islet-1 and found that neural tube and dorsal root ganglion (DRG) cells express Islet-1 after leaving the cell cycle, while sympathetic ganglion (SG) cells express Islet-1 while still dividing.

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Differential expression of Islet-1 in neural crest-derived ganglia: Islet-1 + dorsal root ganglion cells are post-mitotic and Islet-1 + sympathetic ganglion cells are still cycling

Abstract

Bibliographical note

Keywords

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