Differential effects of Th1 and Th2 derived cytokines on NGF synthesis by mouse astrocytes

Chaya Brodie

doi:10.1016/0014-5793(96)00911-8

Differential effects of Th1 and Th2 derived cytokines on NGF synthesis by mouse astrocytes

Chaya Brodie

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

During the course of brain injury and inflammation there is an increased secretion of neurotrophic substances by astrocytes. We have examined the effect of the Th2-derived cytokine IL-10 and the Th1-derived cytokines IL-2 and IFN-γ on the secretion of NGF by mouse astrocytes. IL-10 induced a dose-dependent increase in NGF secretion which was blocked by anti IL-10 antibody. In contrast, the Th1-derived cytokines IFN-γ and IL-2 did not induce NGP synthesis. Moreover, INF-γ completely inhibited the increase in NGF secretion induced by IL-10 whereas it had no effect on the induction of NGF by TNFα. These results indicate that IL-10 similarly to other Th2-derived cytokines may provide a neurotrophic support to injured neurons via the induction of NGF synthesis, whereas the Th1-derived cytokine IFN-γ antagonizes this effect.

Original language	English
Pages (from-to)	117-120
Number of pages	4
Journal	FEBS Letters
Volume	394
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(96)00911-8
State	Published - 30 Sep 1996

Keywords

Astrocyte
Brain inflammation
IFN-γ
IL-10
Nerve growth factor

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10.1016/0014-5793(96)00911-8

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abstract = "During the course of brain injury and inflammation there is an increased secretion of neurotrophic substances by astrocytes. We have examined the effect of the Th2-derived cytokine IL-10 and the Th1-derived cytokines IL-2 and IFN-γ on the secretion of NGF by mouse astrocytes. IL-10 induced a dose-dependent increase in NGF secretion which was blocked by anti IL-10 antibody. In contrast, the Th1-derived cytokines IFN-γ and IL-2 did not induce NGP synthesis. Moreover, INF-γ completely inhibited the increase in NGF secretion induced by IL-10 whereas it had no effect on the induction of NGF by TNFα. These results indicate that IL-10 similarly to other Th2-derived cytokines may provide a neurotrophic support to injured neurons via the induction of NGF synthesis, whereas the Th1-derived cytokine IFN-γ antagonizes this effect.",

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AB - During the course of brain injury and inflammation there is an increased secretion of neurotrophic substances by astrocytes. We have examined the effect of the Th2-derived cytokine IL-10 and the Th1-derived cytokines IL-2 and IFN-γ on the secretion of NGF by mouse astrocytes. IL-10 induced a dose-dependent increase in NGF secretion which was blocked by anti IL-10 antibody. In contrast, the Th1-derived cytokines IFN-γ and IL-2 did not induce NGP synthesis. Moreover, INF-γ completely inhibited the increase in NGF secretion induced by IL-10 whereas it had no effect on the induction of NGF by TNFα. These results indicate that IL-10 similarly to other Th2-derived cytokines may provide a neurotrophic support to injured neurons via the induction of NGF synthesis, whereas the Th1-derived cytokine IFN-γ antagonizes this effect.

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Differential effects of Th1 and Th2 derived cytokines on NGF synthesis by mouse astrocytes

Abstract

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