Abstract
During the course of brain injury and inflammation there is an increased secretion of neurotrophic substances by astrocytes. We have examined the effect of the Th2-derived cytokine IL-10 and the Th1-derived cytokines IL-2 and IFN-γ on the secretion of NGF by mouse astrocytes. IL-10 induced a dose-dependent increase in NGF secretion which was blocked by anti IL-10 antibody. In contrast, the Th1-derived cytokines IFN-γ and IL-2 did not induce NGP synthesis. Moreover, INF-γ completely inhibited the increase in NGF secretion induced by IL-10 whereas it had no effect on the induction of NGF by TNFα. These results indicate that IL-10 similarly to other Th2-derived cytokines may provide a neurotrophic support to injured neurons via the induction of NGF synthesis, whereas the Th1-derived cytokine IFN-γ antagonizes this effect.
| Original language | English |
|---|---|
| Pages (from-to) | 117-120 |
| Number of pages | 4 |
| Journal | FEBS Letters |
| Volume | 394 |
| Issue number | 2 |
| DOIs | |
| State | Published - 30 Sep 1996 |
Keywords
- Astrocyte
- Brain inflammation
- IFN-γ
- IL-10
- Nerve growth factor