Differential effects of Th1 and Th2 derived cytokines on NGF synthesis by mouse astrocytes

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    Abstract

    During the course of brain injury and inflammation there is an increased secretion of neurotrophic substances by astrocytes. We have examined the effect of the Th2-derived cytokine IL-10 and the Th1-derived cytokines IL-2 and IFN-γ on the secretion of NGF by mouse astrocytes. IL-10 induced a dose-dependent increase in NGF secretion which was blocked by anti IL-10 antibody. In contrast, the Th1-derived cytokines IFN-γ and IL-2 did not induce NGP synthesis. Moreover, INF-γ completely inhibited the increase in NGF secretion induced by IL-10 whereas it had no effect on the induction of NGF by TNFα. These results indicate that IL-10 similarly to other Th2-derived cytokines may provide a neurotrophic support to injured neurons via the induction of NGF synthesis, whereas the Th1-derived cytokine IFN-γ antagonizes this effect.

    Original languageEnglish
    Pages (from-to)117-120
    Number of pages4
    JournalFEBS Letters
    Volume394
    Issue number2
    DOIs
    StatePublished - 30 Sep 1996

    Keywords

    • Astrocyte
    • Brain inflammation
    • IFN-γ
    • IL-10
    • Nerve growth factor

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