Differential effects of Th1 and Th2 derived cytokines on NGF synthesis by mouse astrocytes

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

During the course of brain injury and inflammation there is an increased secretion of neurotrophic substances by astrocytes. We have examined the effect of the Th2-derived cytokine IL-10 and the Th1-derived cytokines IL-2 and IFN-γ on the secretion of NGF by mouse astrocytes. IL-10 induced a dose-dependent increase in NGF secretion which was blocked by anti IL-10 antibody. In contrast, the Th1-derived cytokines IFN-γ and IL-2 did not induce NGP synthesis. Moreover, INF-γ completely inhibited the increase in NGF secretion induced by IL-10 whereas it had no effect on the induction of NGF by TNFα. These results indicate that IL-10 similarly to other Th2-derived cytokines may provide a neurotrophic support to injured neurons via the induction of NGF synthesis, whereas the Th1-derived cytokine IFN-γ antagonizes this effect.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalFEBS Letters
Volume394
Issue number2
DOIs
StatePublished - 30 Sep 1996

Keywords

  • Astrocyte
  • Brain inflammation
  • IFN-γ
  • IL-10
  • Nerve growth factor

Fingerprint

Dive into the research topics of 'Differential effects of Th1 and Th2 derived cytokines on NGF synthesis by mouse astrocytes'. Together they form a unique fingerprint.

Cite this