Abstract
Acyclic 1,2-amido alcohols (6) react efficiently with a slight excess of (diethylamino)sulfur trifluoride (DAST) to afford the corresponding 2-oxazolines (10) in good yields ranging between 57-95%. Even at the low temperature of -78 °C, a rapid (< 1 h) and stereoselective amide cyclization is observed without formation of acylaziridine by-products. The scope of this cyclization is discussed.
Original language | American English |
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Pages (from-to) | 947-958 |
Journal | Heterocycles |
Volume | 4 |
Issue number | 41 |
State | Published - 1995 |