Diethyl chlorophosphite: A versatile reagent

Zhou Jie, Vebumani Rammoorty, Bilha Fischer

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Diethyl chlorophosphite (DECP) was previously described as a reducing agent for nitro compounds to the corresponding amines (Fischer, B.; Sheihet, L. J. Org. Chem. 1998, 63, 393). Here, the utility of this reagent was extended to chemical conversions of other oxygenated functional groups. In this paper we report on the scope of the reaction of DECP with N-oxides, epoxides, sulfones, sulfoxides, hydroxylamines, ketoximes, and aldoximes. The chemoselectivity of DECP is described, and conditions for a stepwise multiple conversion of functional groups on the same molecule with this reagent are provided.

Original languageEnglish
Pages (from-to)711-719
Number of pages9
JournalJournal of Organic Chemistry
Issue number3
StatePublished - 8 Feb 2002


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