Development of tolerance in rats to the hypothermic effects of d-amphetamine and apomorphine

Hillel Chiel, Shlomo Yehuda, Richard J. Wurtman

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26 Scopus citations

Abstract

Rats given d-amphetamine (15 mg/kg i.p.) or apomorphine (10 mg/kg i.p.) and placed in a cold environment (4°C) developed marked hypothermia. After daily injections of either drug for seven weeks, the maximal hypothermic responses to d-amphetamine or apomorphine were reduced to 72% and 19% of those obtained initially. Subsequent injection of ET-495, a central dopamine receptor stimulant, caused rectal temperature to decrease only 72% and 49% as much as in control animals. The hypothermic response to apomorphine was also depressed in d-amphetamine-treated animals. These observations suggest that the tolerance to the hypothermic effects of both d-amphetamine and apomorphine that develops is due at least in part to alterations in the sensitivity of dopamine receptors.

Original languageEnglish
Pages (from-to)483-488
Number of pages6
JournalLife Sciences
Volume14
Issue number3
DOIs
StatePublished - 1 Feb 1974
Externally publishedYes

Bibliographical note

Funding Information:
These studies were supported in part by grants (AM-11237 and AM-11709) from the United States Public Health Service . Mr . Chief s stipend for undergraduate summier research was generously provided by the Merck, Sharp ~ Dohme Co .

Funding

These studies were supported in part by grants (AM-11237 and AM-11709) from the United States Public Health Service . Mr . Chief s stipend for undergraduate summier research was generously provided by the Merck, Sharp ~ Dohme Co .

FundersFunder number
U.S. Public Health Service

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