Development of local surface plasmon resonance sensor using gold nanoparticles

Marianna Beiderman; Menachem Motiei; Rachela Popovtzer; Dror Fixler

doi:10.1117/12.2509667

Development of local surface plasmon resonance sensor using gold nanoparticles

Marianna Beiderman, Menachem Motiei, Rachela Popovtzer, Dror Fixler

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The healthcare industry is moving towards personalized medicine and patients seek greater role in their care. In this paper we describe a proof of concept of versatile optical sensor that potentially can be used for in vivo detection of biological events. The developed sensor comprises of a silver thin film glass slide and gold nanoparticles (GNPs) and allows detection of chemical changes using surface plasmon resonance (SPR), local surface plasmon resonance (LSPR) and fluorescence lifetime detection modalities. A change in spectrum was observed after removal of GNPs by 2-mercaptoethanol. Moreover, GNP conjugated to fluorescein were tested using fluorescence lifetime microscopy (FLIM) to enhance sensing capabilities and provide additional dimension for detection. The sensor has the potential to provide real-time analyses of different biological molecules, such as antibody and antigen, receptor and ligand, and complementary DNA fragments.

Original language	English
Title of host publication	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI
Editors	Ewa M. Goldys, Dror Fixler, Dan V. Nicolau
Publisher	SPIE
ISBN (Electronic)	9781510624245
DOIs	https://doi.org/10.1117/12.2509667
State	Published - 2019
Event	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI 2019 - San Francisco, United States Duration: 3 Feb 2019 → 4 Feb 2019

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	10891
ISSN (Print)	1605-7422

Conference

Conference	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI 2019
Country/Territory	United States
City	San Francisco
Period	3/02/19 → 4/02/19

Bibliographical note

Publisher Copyright:
© 2019 SPIE.

Funding

The work described in this proceeding is supported by the Israeli Ministry of Science, Technology, and

Funders	Funder number
Israeli ministry of science, technology

Keywords

Fluorescence lifetime imaging
Gold nanoparticles
Local Surface Plasmon Resonance (LSPR)

Access to Document

10.1117/12.2509667

Cite this

Beiderman, M., Motiei, M., Popovtzer, R., & Fixler, D. (2019). Development of local surface plasmon resonance sensor using gold nanoparticles. In E. M. Goldys, D. Fixler, & D. V. Nicolau (Eds.), Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI Article 108910O (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10891). SPIE. https://doi.org/10.1117/12.2509667

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title = "Development of local surface plasmon resonance sensor using gold nanoparticles",

abstract = "The healthcare industry is moving towards personalized medicine and patients seek greater role in their care. In this paper we describe a proof of concept of versatile optical sensor that potentially can be used for in vivo detection of biological events. The developed sensor comprises of a silver thin film glass slide and gold nanoparticles (GNPs) and allows detection of chemical changes using surface plasmon resonance (SPR), local surface plasmon resonance (LSPR) and fluorescence lifetime detection modalities. A change in spectrum was observed after removal of GNPs by 2-mercaptoethanol. Moreover, GNP conjugated to fluorescein were tested using fluorescence lifetime microscopy (FLIM) to enhance sensing capabilities and provide additional dimension for detection. The sensor has the potential to provide real-time analyses of different biological molecules, such as antibody and antigen, receptor and ligand, and complementary DNA fragments.",

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Beiderman, M, Motiei, M, Popovtzer, R & Fixler, D 2019, Development of local surface plasmon resonance sensor using gold nanoparticles. in EM Goldys, D Fixler & DV Nicolau (eds), Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI., 108910O, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10891, SPIE, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI 2019, San Francisco, United States, 3/02/19. https://doi.org/10.1117/12.2509667

Development of local surface plasmon resonance sensor using gold nanoparticles. / Beiderman, Marianna; Motiei, Menachem; Popovtzer, Rachela et al.
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI. ed. / Ewa M. Goldys; Dror Fixler; Dan V. Nicolau. SPIE, 2019. 108910O (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10891).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Development of local surface plasmon resonance sensor using gold nanoparticles

Abstract

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Bibliographical note

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Keywords

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