TY - JOUR
T1 - Development of cervical and vaginal squamous cell neoplasia as a late consequence of in utero exposure to diethylstilbestrol
AU - Bornstein, Jacob
AU - Adam, Ervin
AU - Kaufman, Raymond H.
PY - 1988/1
Y1 - 1988/1
N2 - During the last 14 years, several articles have given contradictory reports on prevalence rates of squamous cell neoplasia of the cervix and vagina in diethylstilbestrol DES exposed progeny. In 1984, the DES Adenosis DESAD Project found that the incidence of cervical and vaginal intraepithelial neoplasia in DES exposed daughters was twice as high as in a comparison group of unexposed women. This was also associated with a higher rate of herpes simplex virus and human papillomavirus infections. Possible hypotheses on the etiology of the increased incidence of squamous neoplasia are discussed.
AB - During the last 14 years, several articles have given contradictory reports on prevalence rates of squamous cell neoplasia of the cervix and vagina in diethylstilbestrol DES exposed progeny. In 1984, the DES Adenosis DESAD Project found that the incidence of cervical and vaginal intraepithelial neoplasia in DES exposed daughters was twice as high as in a comparison group of unexposed women. This was also associated with a higher rate of herpes simplex virus and human papillomavirus infections. Possible hypotheses on the etiology of the increased incidence of squamous neoplasia are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0023818476&partnerID=8YFLogxK
U2 - 10.1097/00006254-198801000-00002
DO - 10.1097/00006254-198801000-00002
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C2 - 2829071
AN - SCOPUS:0023818476
SN - 0029-7828
VL - 43
SP - 15
EP - 21
JO - Obstetrical and Gynecological Survey
JF - Obstetrical and Gynecological Survey
IS - 1
ER -