Development of bursa of Fabricius in relations to humoral immunity in chicken embryo

Rajesh Kumar, G. K. Singh, R. S. Chauhan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Lymphoblastogenesis assay, using lipopolysaccharide (LPS) as mitogen, revealed blast formation by B-lymphocytes only at 21st day but not at the 16th day of incubation. Enzyme linked immunosorbent assay suggested the presence of IgG IgM antibodies at both 16th and 21st day of incubation, indicating the presence of the maternal antibodies in embryonic blood even before the development of the embryonic immunity. Histoarchitecture of the bursa of Fabricius underwent marked changes during 16th to 21st day of incubation. There was increase in the number of the bursal follicles at 21st day. Follicles were well arranged with a fine network of reticular and collagen fibres around follicles at 21st day. All these changes favoured the production of functional B-lymphocytes by the bursa of Fabricius at 21 day of incubation.

Original languageEnglish
Pages (from-to)838-840
Number of pages3
JournalIndian Journal of Animal Sciences
Issue number8
StatePublished - Aug 2004
Externally publishedYes


  • Bursa of fabricius
  • Chicken
  • Embryo
  • Humoral immunity


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