Detection of small subendocardial infarction using speckle tracking echocardiography in a rat model

Noa Bachner-Hinenzon, Liron Shlomo, Hanan Khamis, Offir Ertracht, Zvi Vered, Assaf Malka, Ofer Binah, Dan Adam

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: It is challenging to detect small nontransmural infarcts visually or automatically. As it is important to detect myocardial infarction (MI) at early stages, we tested the hypothesis that small nontransmural MI can be detected using speckle tracking echocardiography (STE) at the acute stage. Methods: Minimal nontransmural infarcts were induced in 18 rats by causing recurrent ischemia–reperfusion of the left anterior descending (LAD) coronary artery, followed by a 30-min ligation and by reperfusion. A week later, the scar size was measured by histological analysis. Each rat underwent three echocardiography measurements: at baseline, 1 day post-MI, and 1 week post-MI. To measure the peak circumferential strain (CS), peak systolic CS, radial strain (RS), and time-to-peak (TTP) of the CS, short-axis view of the apex was analyzed by a STE program. The TTP was normalized by the duration of the heart cycle to create percent change of heart cycle. Results: Histological analysis after 1 week showed scar size of 4±6% at the anterior wall. At 24 h post-MI, the peak CS, peak systolic CS, and RS were reduced compared to baseline at the anterior wall due to the MI, and at the adjacent segments—the anterior septum and lateral wall, due to stunning (P<.05). However, only the anterior wall, the genuine damaged segment, showed prolonged TTP vs baseline (baseline 36%, 24 h 48%, P<.05). Conclusion: The TTP of the CS can distinguish between regions adjacent to MI (stunned or tethered) and MI, even in small nontransmural infarcts.

Original languageEnglish
Pages (from-to)1571-1578
Number of pages8
Issue number10
StatePublished - 1 Oct 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016, Wiley Periodicals, Inc.


  • myocardial infarction
  • myocardial strain
  • stunning
  • viability


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