Detection of cancer by means of infrared spectroscopy

Yitzhak Weissman, Aharon Bonstein, Tania Babushkin, Zvi Malik, Arie Ornstein

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


We have measured the mid-infrared spectra of several tissues in a malignant and normal state, using the ATR sampling method. The aim of the experiments was to detect cancer signatures that were discovered earlier using other sampling methods. The ATR method is particularly attractive for medical applications because it can be used in-vivo, and because it requires minimal sample preparation. We have succeeded to detect a significant signature in only one of the five spectral bands that were examined. This signature is attributed to the PO2- symmetric stretching of the nucleic acids phosphodiester groups, and is located in the vicinity of 1082 cm-1. The signature consists of a shift in the maximum absorption peak by 3 cm -1. The measured data is in good agreement with the published data. This result can lead to real-time tumor mapping during surgery and in-vivo cancer diagnosis with fiber-optic ATR probes.

Original languageEnglish
Pages (from-to)585-591
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1997
Event10th Meeting on Optical Engineering in Israel - Jerusalem, Israel
Duration: 2 Mar 19972 Mar 1997


  • Attenuated total reflection
  • Cancer detection
  • Infra-red spectroscopy
  • Optical biopsy


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