TY - GEN
T1 - Detecting ionic currents in single channels using wavelet analysis, part I
T2 - Wavelet Applications in Signal and Image Processing II
AU - Averbuch, Amir
AU - Eisenberg, R. S.
AU - Israeli, M.
AU - Schuss, Z.
PY - 1994
Y1 - 1994
N2 - The patch clamp technique opened a new field in biological research and shed light on membrane permittivity for ionic currents. The key element in patch clamp measurements is the detection of the ionic currents in a single biological channel. It is known that the channels open and close at random times, thus modulating the ionic currents. The measured current switches between two levels corresponding to the open and close states of the channel. Determining the statistics of the open and closed periods is of crucial importance to the experimenter, because it reflects the response of channel protein to drugs and other factors. The detected signal is strongly corrupted by instrumentation and other noises, rendering the detection of the opening and closing moments extremely difficult. We describe the use of the wavelet transform and its associated multiresolution (multiscale) analysis to detect the currents through single ionic channels corrupted with noise.
AB - The patch clamp technique opened a new field in biological research and shed light on membrane permittivity for ionic currents. The key element in patch clamp measurements is the detection of the ionic currents in a single biological channel. It is known that the channels open and close at random times, thus modulating the ionic currents. The measured current switches between two levels corresponding to the open and close states of the channel. Determining the statistics of the open and closed periods is of crucial importance to the experimenter, because it reflects the response of channel protein to drugs and other factors. The detected signal is strongly corrupted by instrumentation and other noises, rendering the detection of the opening and closing moments extremely difficult. We describe the use of the wavelet transform and its associated multiresolution (multiscale) analysis to detect the currents through single ionic channels corrupted with noise.
UR - http://www.scopus.com/inward/record.url?scp=0028737817&partnerID=8YFLogxK
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AN - SCOPUS:0028737817
SN - 0819416274
T3 - Proceedings of SPIE - The International Society for Optical Engineering
SP - 76
EP - 90
BT - Proceedings of SPIE - The International Society for Optical Engineering
PB - Society of Photo-Optical Instrumentation Engineers
Y2 - 27 July 1994 through 29 July 1994
ER -