Designing RNA switches for synthetic biology using inverse-RNA-folding

Sumit Mukherjee; Danny Barash

doi:10.1016/j.tibtech.2023.11.005

Designing RNA switches for synthetic biology using inverse-RNA-folding

Sumit Mukherjee, Danny Barash

Research output: Contribution to journal › Short survey › peer-review

7 Scopus citations

Abstract

RNA switches respond to specific ligands to control gene expression. They are widely used in synthetic biology applications and hold potential for future RNA-based therapeutic breakthroughs. However, the crux is their precise design. Here, we will discuss how inverse-RNA-folding could be utilized for the accurate design of RNA switches.

Original language	English
Pages (from-to)	517-521
Number of pages	5
Journal	Trends in Biotechnology
Volume	42
Issue number	5
Early online date	30 Nov 2023
DOIs	https://doi.org/10.1016/j.tibtech.2023.11.005
State	Published - May 2024
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Ltd

Funding

S.M. and D.B. would like to thank the Lynne and William Frankel Center for Computer Science at Ben-Gurion University, where the concept of this paper was designed and the research was performed. S.M. would like to acknowledge the National Institutes of Health (NIH), USA, for providing Intramural Postdoctoral Visiting Fellowship. S.M. received the NIH Fellows Award for Research Excellence (FARE 2024). Figures were created with BioRender.com. We acknowledge that due to the format restrictions for this forum article, we were unable to include several relevant references, including important ones related to the methodology of inverse-RNA-folding. No interests are declared by the authors. S.M. and D.B. would like to thank the Lynne and William Frankel Center for Computer Science at Ben-Gurion University, where the concept of this paper was designed and the research was performed. S.M. would like to acknowledge the National Institutes of Health (NIH), USA, for providing Intramural Postdoctoral Visiting Fellowship. S.M. received the NIH Fellows Award for Research Excellence (FARE 2024). Figures were created with BioRender.com . We acknowledge that due to the format restrictions for this forum article, we were unable to include several relevant references, including important ones related to the methodology of inverse-RNA-folding.

Funders	Funder number
Lynne and William Frankel Center for Computer Science
National Institutes of Health	FARE 2024

Keywords

RNA switch
RNA-based therapeutics
inverse-RNA-folding
riboswitch
ribozyme
synthetic biology

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10.1016/j.tibtech.2023.11.005

Cite this

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Designing RNA switches for synthetic biology using inverse-RNA-folding

Abstract

Bibliographical note

Funding

Keywords

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