Design of novel BSA/hyaluronic acid nanodispersions for transdermal pharma purposes

Madalena Martins; Nuno G. Azoia; Ulyana Shimanovich; Teresa Matamá; Andreia C. Gomes; Carla Silva; Artur Cavaco-Paulo

doi:10.1021/mp400657g

Design of novel BSA/hyaluronic acid nanodispersions for transdermal pharma purposes

Madalena Martins, Nuno G. Azoia, Ulyana Shimanovich, Teresa Matamá, Andreia C. Gomes, Carla Silva, Artur Cavaco-Paulo

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A novel transdermal hyaluronic acid (HA) conjugated with bovine serum albumin (BSA) was developed in the form of solid-in-oil (S/O) nanodispersion (129.7 nm mean diameter). Ex vivo skin penetration analysis by fluorescence and confocal observation of histological skin sections revealed the ability of BSA/HA nanodispersions to cross the stratum corneum and penetrate into the dermis. Furthermore, no significant toxicity was found in fibroblast and keratinocyte cells in vitro. These results proved the potential of the developed nanodispersion for transdermal delivery of hyaluronic acid constituting a high value to biopharmaceutical and cosmetics industries.

Original language	English
Pages (from-to)	1479-1488
Number of pages	10
Journal	Molecular Pharmaceutics
Volume	11
Issue number	5
DOIs	https://doi.org/10.1021/mp400657g
State	Published - 5 May 2014
Externally published	Yes

Keywords

bovine serum albumin
hyaluronic acid
nanodispersion
skin penetration
transdermal transport

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10.1021/mp400657g

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abstract = "A novel transdermal hyaluronic acid (HA) conjugated with bovine serum albumin (BSA) was developed in the form of solid-in-oil (S/O) nanodispersion (129.7 nm mean diameter). Ex vivo skin penetration analysis by fluorescence and confocal observation of histological skin sections revealed the ability of BSA/HA nanodispersions to cross the stratum corneum and penetrate into the dermis. Furthermore, no significant toxicity was found in fibroblast and keratinocyte cells in vitro. These results proved the potential of the developed nanodispersion for transdermal delivery of hyaluronic acid constituting a high value to biopharmaceutical and cosmetics industries.",

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AU - Martins, Madalena

AU - Azoia, Nuno G.

AU - Shimanovich, Ulyana

AU - Matamá, Teresa

AU - Gomes, Andreia C.

AU - Silva, Carla

AU - Cavaco-Paulo, Artur

PY - 2014/5/5

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AB - A novel transdermal hyaluronic acid (HA) conjugated with bovine serum albumin (BSA) was developed in the form of solid-in-oil (S/O) nanodispersion (129.7 nm mean diameter). Ex vivo skin penetration analysis by fluorescence and confocal observation of histological skin sections revealed the ability of BSA/HA nanodispersions to cross the stratum corneum and penetrate into the dermis. Furthermore, no significant toxicity was found in fibroblast and keratinocyte cells in vitro. These results proved the potential of the developed nanodispersion for transdermal delivery of hyaluronic acid constituting a high value to biopharmaceutical and cosmetics industries.

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KW - skin penetration

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Design of novel BSA/hyaluronic acid nanodispersions for transdermal pharma purposes

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