Design of novel BSA/hyaluronic acid nanodispersions for transdermal pharma purposes

Madalena Martins, Nuno G. Azoia, Ulyana Shimanovich, Teresa Matamá, Andreia C. Gomes, Carla Silva, Artur Cavaco-Paulo

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


A novel transdermal hyaluronic acid (HA) conjugated with bovine serum albumin (BSA) was developed in the form of solid-in-oil (S/O) nanodispersion (129.7 nm mean diameter). Ex vivo skin penetration analysis by fluorescence and confocal observation of histological skin sections revealed the ability of BSA/HA nanodispersions to cross the stratum corneum and penetrate into the dermis. Furthermore, no significant toxicity was found in fibroblast and keratinocyte cells in vitro. These results proved the potential of the developed nanodispersion for transdermal delivery of hyaluronic acid constituting a high value to biopharmaceutical and cosmetics industries.

Original languageEnglish
Pages (from-to)1479-1488
Number of pages10
JournalMolecular Pharmaceutics
Issue number5
StatePublished - 5 May 2014
Externally publishedYes


  • bovine serum albumin
  • hyaluronic acid
  • nanodispersion
  • skin penetration
  • transdermal transport


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