Abstract
The small molecule anticancer agent cisplatin and its Pt(II) analogs carboplatin and oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural simplicity, side effects and disadvantages, they are cornerstones of cancer chemotherapy. Several strategies have been pursued to enhance the activity and reduce the side effects of metal-based drugs, for example, to use bioactive ligands that equip them with novel modes of action, enhance delivery, allow for selective activation, create synergistic effects or improve tumor accumulation. Many of these strategies have been developed for or adapted in the design of half-sandwich organoruthenium compounds. For such compounds decorated with bioactive ligands that coordinate monodentately to the Ru center, we have identified five design concepts (Coord. Chem. Rev. 2021, 439, 213890): (i) the bioactive ligand coordinates directly to the Ru center or (ii) after functionalization with a coordinating group, (iii) the ligand(s) and the Ru center solely define the overall shape of the molecule, (iv) the bioactive ligand is released, and (v) the bioactive ligand acts as a vector to the tumor (cell). Herein, we use these five concepts and explore their application to half-sandwich organoruthenium anticancer compounds in which the bioactive ligand is coordinated to the Ru center through a bidentate chelating motif.
Original language | English |
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Article number | 213950 |
Journal | Coordination Chemistry Reviews |
Volume | 445 |
DOIs | |
State | Published - 15 Oct 2021 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2021 Elsevier B.V.
Funding
We thank all students, PostDocs and collaborators who have contributed to the work that was reviewed in this publication. We would like to thank the University of Auckland, the Marsden Fund Council, managed by the Royal Society Te Apārangi, and the Cancer Research Trust for financial support. T.R.S., S.K. and D.M.G. are grateful to the University of Auckland for University of Auckland Doctoral Scholarships. M.P.S. is supported by a Faculty Research Development Fund project of the University of Auckland. M.H. thanks the Health Research Council of New Zealand for a Sir Charles Hercus Fellowship. A.W.B. is grateful to the Polish National Agency for Academic Exchange for a Bekker Scholarship (PPN/BEK/2018/1/00492). A part of the graphical abstract was created with BioRender.com. We thank all students, PostDocs and collaborators who have contributed to the work that was reviewed in this publication. We would like to thank the University of Auckland, the Marsden Fund Council, managed by the Royal Society Te Apārangi, and the Cancer Research Trust for financial support. T.R.S. S.K. and D.M.G. are grateful to the University of Auckland for University of Auckland Doctoral Scholarships. M.P.S. is supported by a Faculty Research Development Fund project of the University of Auckland. M.H. thanks the Health Research Council of New Zealand for a Sir Charles Hercus Fellowship. A.W.B. is grateful to the Polish National Agency for Academic Exchange for a Bekker Scholarship (PPN/BEK/2018/1/00492). A part of the graphical abstract was created with BioRender.com.
Funders | Funder number |
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Cancer Research Trust | |
Health Research Council of New Zealand for a Sir Charles Hercus Fellowship | |
Marsden Fund Council | |
University of Auckland for University of Auckland | |
Royal Society Te Apārangi | |
University of Auckland | |
Narodowa Agencja Wymiany Akademickiej | PPN/BEK/2018/1/00492 |
Keywords
- 16HBE
- ARPE-19
- African green monkey kidney cells
- Anticancer agents
- BEAS-2B
- BGM
- Bidentate bioactive ligands
- Bioorganometallics
- Buffalo Green Monkey kidney cells
- CA-M75
- CHO
- Chinese hamster ovary cells
- EA.hy 926
- FG0
- HEK
- HEK-293 T, human embryonic kidney
- HEK-293, human embryonic kidney
- HEK-293T
- HEK293
- HFF-1
- HL-7702
- HLF
- HUVEC
- HaCaT
- IMR-90
- KMST-6
- L929
- LLC-PK1
- MCF-10A
- MDBK
- MRC-5
- MS1
- Metallodrugs
- Mode of action
- NIH-3T3
- PBMC
- RAW264.7
- Raw-264.7, mouse macrophage
- Synergistic activity
- Vero
- bovine kidney epithelium
- human breast epithelium
- human embryonal lung fibroblast
- human embryonic fibroblast
- human embryonic kidney
- human epidermal keratinocyte
- human foreskin fibroblast
- human liver cells
- human lung bronchial epithelium
- human lung fibroblast
- human lung fibroblast-1
- human peripheral blood mononuclear cells
- human retinal pigment epithelium
- human umbilical vein endothelium
- lung epithelium
- mouse embryonic fibroblast
- mouse fibroblast
- murine endothelium
- pig kidney epithelium
- skin fibroblasts
- skin melanocyte
- transformed human umbilical vein endothelium