Abstract
A masked combination chemotherapy which relies on the embedding of a number of active components, in a latent form, within a single endoperoxidic chemical entity is the aim of the research presented. The approach is illustrated by means of purposely designed bicyclic endoperoxide prodrug prototypes 1 and subsequently validated through the study of model compounds 2 (Ar= Ph, p-FC 6H4, p-ClC6H4.
Original language | English |
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Pages (from-to) | 4193-4197 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 43 |
Issue number | 32 |
DOIs | |
State | Published - 13 Aug 2004 |
Externally published | Yes |
Keywords
- Antimalarial agents
- Chalcones
- Combination chemotherapy
- Cysteine protease inhibitors
- Endoperoxides