A masked combination chemotherapy which relies on the embedding of a number of active components, in a latent form, within a single endoperoxidic chemical entity is the aim of the research presented. The approach is illustrated by means of purposely designed bicyclic endoperoxide prodrug prototypes 1 and subsequently validated through the study of model compounds 2 (Ar= Ph, p-FC 6H4, p-ClC6H4.
|Number of pages||5|
|Journal||Angewandte Chemie - International Edition|
|State||Published - 13 Aug 2004|
- Antimalarial agents
- Combination chemotherapy
- Cysteine protease inhibitors