TY - JOUR
T1 - Dendritic Learning as a Paradigm Shift in Brain Learning
AU - Sardi, Shira
AU - Vardi, Roni
AU - Goldental, Amir
AU - Tugendhaft, Yael
AU - Uzan, Herut
AU - Kanter, Ido
N1 - Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/6/20
Y1 - 2018/6/20
N2 - Experimental and theoretical results reveal a new underlying mechanism for fast brain learning process, dendritic learning, as opposed to the misdirected research in neuroscience over decades, which is based solely on slow synaptic plasticity. The presented paradigm indicates that learning occurs in closer proximity to the neuron, the computational unit, dendritic strengths are self-oscillating, and weak synapses, which comprise the majority of our brain and previously were assumed to be insignificant, play a key role in plasticity. The new learning sites of the brain call for a reevaluation of current treatments for disordered brain functionality and for a better understanding of proper chemical drugs and biological mechanisms to maintain, control and enhance learning.
AB - Experimental and theoretical results reveal a new underlying mechanism for fast brain learning process, dendritic learning, as opposed to the misdirected research in neuroscience over decades, which is based solely on slow synaptic plasticity. The presented paradigm indicates that learning occurs in closer proximity to the neuron, the computational unit, dendritic strengths are self-oscillating, and weak synapses, which comprise the majority of our brain and previously were assumed to be insignificant, play a key role in plasticity. The new learning sites of the brain call for a reevaluation of current treatments for disordered brain functionality and for a better understanding of proper chemical drugs and biological mechanisms to maintain, control and enhance learning.
KW - Learning
KW - deep learning
KW - degenerative diseases
KW - dendrites
KW - synaptic plasticity
UR - http://www.scopus.com/inward/record.url?scp=85048837704&partnerID=8YFLogxK
U2 - 10.1021/acschemneuro.8b00204
DO - 10.1021/acschemneuro.8b00204
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C2 - 29727167
AN - SCOPUS:85048837704
SN - 1948-7193
VL - 9
SP - 1230
EP - 1232
JO - ACS Chemical Neuroscience
JF - ACS Chemical Neuroscience
IS - 6
ER -