Decreased homotopic functional connectivity in traumatic brain injury

Reut Raizman, Nofar Itzhaki, Johanna Sirkin, Inbar Meningher, Galia Tsarfaty, Ofer Keren, Zion Zibli, Tamar Silberg, Chaim G. Pick, Abigail Livny

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Introduction: Homotopic functional connectivity (HoFC), the synchrony in activity patterns between homologous brain regions, is a fundamental characteristic of resting-state functional connectivity (RsFC). Methods: We examined the difference in HoFC, computed as the correlation between atlas-based regions and their counterpart on the opposite hemisphere, in 16 moderate-severe traumatic brain injury patients (msTBI) and 36 healthy controls. Regions of decreased HoFC in msTBI patients were further used as seeds for examining differences between groups in correlations with other brain regions. Finally, we computed logistic regression models of regional HoFC and fractional anisotropy (FA) of the corpus callosum (CC). Results: TBI patients exhibited decreased HoFC in the middle and posterior cingulate cortex, thalamus, superior temporal pole, and cerebellum III. Furthermore, decreased RsFC was found between left cerebellum III and right parahippocampal cortex and vermis, between superior temporal pole and left caudate and medial left and right frontal orbital gyri. Thalamic HoFC and FA of the CC discriminate patients as msTBI with a high accuracy of 96%. Conclusion: TBI is associated with regionally decreased HoFC. Moreover, a multimodality model of interhemispheric connectivity allowed for a high degree of accuracy in disease discrimination and enabled a deeper understanding of TBI effects on brain interhemispheric reorganization post-TBI.

Original languageEnglish
Pages (from-to)1207-1216
Number of pages10
JournalCerebral Cortex
Issue number4
StatePublished - 7 Feb 2023

Bibliographical note

Publisher Copyright:
© 2022 The Author(s). Published by Oxford University Press. All rights reserved.


  • MRI
  • functional connectivity
  • homotopy
  • structural integrity
  • traumatic brain injury


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