Decoding of dopaminergic mesolimbic activity and depressive behavior

Alexander Friedman; Ilana Deri; Yaakov Friedman; Eliyahu Dremencov; Sophia Goutkin; Elizabeth Kravchinsky; Matti Mintz; Dino Levi; David H. Overstreet; Gal Yadid

doi:10.1007/s12031-007-0016-5

Decoding of dopaminergic mesolimbic activity and depressive behavior

Alexander Friedman, Ilana Deri, Yaakov Friedman, Eliyahu Dremencov, Sophia Goutkin, Elizabeth Kravchinsky, Matti Mintz, Dino Levi, David H. Overstreet, Gal Yadid

The Mina and Everard Goodman Faculty of Life Sciences - at Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Dopaminergic mesolimbic and mesocortical systems are involved in hedonia and motivation, two core symptoms of depression. However, their role in the pathophysiology of depression and their manipulation to treat depression has received little attention. Previously, we showed decreased limbic dopamine (DA) neurotransmission in an animal model of depression, Flinder sensitive line (FSL) rats. Here we describe a high correlation between phase-space algorithm of bursting-like activity of DA cells in the ventral tegmental area (VTA) and efficiency of DA release in the accumbens. This bursting-like activity of VTA DA cells of FSL rats is characterized by a low dimension complexity. Treatment with the antidepressant desipramine affected both the dimension complexity of cell firing in the VTA and rate of DA release in the accumbens, as well as alleviating depressive-like behavior. Our findings indicate the potential usefulness of monitoring limbic dopaminergic dynamics in combination with non-linear analysis. Decoding the functionality of the dopaminergic system may help in development of future antidepressant drugs.

Original language	English
Pages (from-to)	72-79
Number of pages	8
Journal	Journal of Molecular Neuroscience
Volume	32
Issue number	1
DOIs	https://doi.org/10.1007/s12031-007-0016-5
State	Published - May 2007

Bibliographical note

Funding Information:
Acknowledgements This study was supported in part by a grant from The Israel Science Foundation to GY. We wish to thank Professors Moshe Abeles and Uziel Sandier for critically reviewing the manuscript and Dr. Barbara Schick for her comments.

Funding

Acknowledgements This study was supported in part by a grant from The Israel Science Foundation to GY. We wish to thank Professors Moshe Abeles and Uziel Sandier for critically reviewing the manuscript and Dr. Barbara Schick for her comments.

Funders	Funder number
Israel Science Foundation

Keywords

Dimension analysis
Dopamine
Electrophysiology
Flinders Sensitive Line of rats
Motivation
Nonlinear analysis
Swim test
Ventral tegmental area

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10.1007/s12031-007-0016-5

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abstract = "Dopaminergic mesolimbic and mesocortical systems are involved in hedonia and motivation, two core symptoms of depression. However, their role in the pathophysiology of depression and their manipulation to treat depression has received little attention. Previously, we showed decreased limbic dopamine (DA) neurotransmission in an animal model of depression, Flinder sensitive line (FSL) rats. Here we describe a high correlation between phase-space algorithm of bursting-like activity of DA cells in the ventral tegmental area (VTA) and efficiency of DA release in the accumbens. This bursting-like activity of VTA DA cells of FSL rats is characterized by a low dimension complexity. Treatment with the antidepressant desipramine affected both the dimension complexity of cell firing in the VTA and rate of DA release in the accumbens, as well as alleviating depressive-like behavior. Our findings indicate the potential usefulness of monitoring limbic dopaminergic dynamics in combination with non-linear analysis. Decoding the functionality of the dopaminergic system may help in development of future antidepressant drugs.",

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Decoding of dopaminergic mesolimbic activity and depressive behavior

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