Dcp1a phosphorylation along neuronal development and stress

Jacob Blumenthal; Leah Behar; Evan Elliott; Irith Ginzburg

doi:10.1016/j.febslet.2008.12.002

Dcp1a phosphorylation along neuronal development and stress

Jacob Blumenthal, Leah Behar, Evan Elliott, Irith Ginzburg

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Decapping protein 1a (Dcp1a) is found in P-bodies and functions in mRNA cap removal prior to its degradation. The function and binding partners of Dcp1a have been thoroughly studied, however its expression pattern is still unclear. In this study we have monitored Dcp1a expression along brain development, neuronal differentiation and during cellular stress. We found that Dcp1a is hyperphosphorylated under these physiological conditions. We followed our observations and identified the specific amino acid residues that are phosphorylated. These findings suggest a novel post-translational modification that may influence the function of Dcp1a in response to various physiological cues.

Original language	English
Pages (from-to)	197-201
Number of pages	5
Journal	FEBS Letters
Volume	583
Issue number	1
DOIs	https://doi.org/10.1016/j.febslet.2008.12.002
State	Published - 5 Jan 2009
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported in part by Israel Science Foundation Grant 03454, by the Benoziyo Center for Neurological Diseases, and the Mario-Negri/Weizmann Foundation. I.G. is the incumbent of the Sophie and Richard S. Richards Professorial Chair in Cancer Research.

Funding

This work was supported in part by Israel Science Foundation Grant 03454, by the Benoziyo Center for Neurological Diseases, and the Mario-Negri/Weizmann Foundation. I.G. is the incumbent of the Sophie and Richard S. Richards Professorial Chair in Cancer Research.

Funders	Funder number
Mario-Negri/Weizmann Foundation
Nella and Leon Benoziyo Center for Neurological Diseases, Weizmann Institute of Science
Israel Science Foundation	03454

Keywords

Arsenate
Dcp1a
Neuronal development
P-bodies
Stress granules

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10.1016/j.febslet.2008.12.002

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abstract = "Decapping protein 1a (Dcp1a) is found in P-bodies and functions in mRNA cap removal prior to its degradation. The function and binding partners of Dcp1a have been thoroughly studied, however its expression pattern is still unclear. In this study we have monitored Dcp1a expression along brain development, neuronal differentiation and during cellular stress. We found that Dcp1a is hyperphosphorylated under these physiological conditions. We followed our observations and identified the specific amino acid residues that are phosphorylated. These findings suggest a novel post-translational modification that may influence the function of Dcp1a in response to various physiological cues.",

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AU - Ginzburg, Irith

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Dcp1a phosphorylation along neuronal development and stress

Abstract

Bibliographical note

Funding

Keywords

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