DAMPs as mediators of sterile inflammation in aging-related pathologies

Noa Feldman, Aviva Rotter-Maskowitz, Eitan Okun

Research output: Contribution to journalReview articlepeer-review

210 Scopus citations

Abstract

Accumulating evidence indicates that aging is associated with a chronic low-level inflammation, termed sterile-inflammation. Sterile-inflammation is a form of pathogen-free inflammation caused by mechanical trauma, ischemia, stress or environmental conditions such as ultra-violet radiation. These damage-related stimuli induce the secretion of molecular agents collectively termed danger-associated molecular patterns (DAMPs). DAMPs are recognized by virtue of specialized innate immune receptors, such as toll-like receptors (TLRs) and NOD-like receptor family, pyrin domain containing 3 (NLRP3). These receptors initiate signal transduction pathways, which typically drive inflammation in response to microbe-associated molecular patterns (MAMPs) and/or DAMPs. This review summarizes the current knowledge on DAMPs-mediated sterile-inflammation, its associated downstream signaling, and discusses the possibility that DAMPs activating TLRs or NLRP3 complex mediate sterile inflammation during aging and in aging-related pathologies.

Original languageEnglish
Pages (from-to)29-39
Number of pages11
JournalAgeing Research Reviews
Volume24
DOIs
StatePublished - 1 Nov 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.

Keywords

  • Aging
  • DAMP
  • Inflammasome
  • NLRP3
  • Sterile-inflammation
  • TLR

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