TY - JOUR
T1 - Cytomegalovirus pneumonia complicating immune checkpoint inhibitors-induced pneumonitis
T2 - A case report
AU - Badran, Omar
AU - Ouryvaev, Anton
AU - Baturov, Veronika
AU - Shai, Ayelet
N1 - Publisher Copyright:
© 2021, Spandidos Publications. All rights reserved.
PY - 2021/6
Y1 - 2021/6
N2 - A 63-year-old man was hospitalized for immune check-point inhibitors (ICIs) medicated pneumonitis, secondary to treatment with pembrolizumab for non-small cell lung cancer. He was treated with high dose steroids, mycophenolate mofetil, empiric broad spectrum antibiotics and empiric trimethoprim-sulfamethoxazole and intravenous immunoglobulin. Despite the aforementioned treatment, his condition continued to deteriorate. The patient was admitted to the intensive care unit. While intubated, he underwent bronchoscopy and lavage, which was analyzed for potential infectious agents. Cytomegalovirus (CMV) pneumonia was diagnosed and treated. He passed away despite antiviral treatment and maximal supportive care. CMV infection should be suspected in patients failing to recover from toxicities of ICIs with appropriate immunosuppression.
AB - A 63-year-old man was hospitalized for immune check-point inhibitors (ICIs) medicated pneumonitis, secondary to treatment with pembrolizumab for non-small cell lung cancer. He was treated with high dose steroids, mycophenolate mofetil, empiric broad spectrum antibiotics and empiric trimethoprim-sulfamethoxazole and intravenous immunoglobulin. Despite the aforementioned treatment, his condition continued to deteriorate. The patient was admitted to the intensive care unit. While intubated, he underwent bronchoscopy and lavage, which was analyzed for potential infectious agents. Cytomegalovirus (CMV) pneumonia was diagnosed and treated. He passed away despite antiviral treatment and maximal supportive care. CMV infection should be suspected in patients failing to recover from toxicities of ICIs with appropriate immunosuppression.
KW - Cytomegalovirus pneumonia
KW - Immunosuppressive therapy
KW - Immunotherapy
KW - Non-small cell lung cancer
UR - http://www.scopus.com/inward/record.url?scp=85105127225&partnerID=8YFLogxK
U2 - 10.3892/mco.2021.2282
DO - 10.3892/mco.2021.2282
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C2 - 33903826
AN - SCOPUS:85105127225
SN - 2049-9450
VL - 14
JO - Molecular and Clinical Oncology
JF - Molecular and Clinical Oncology
IS - 6
M1 - 120
ER -
