Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis

Roie Fisher, Ohad Ronen

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


It is important to define the accuracy of fine-needle aspiration cytology (FNAC) in the diagnosis of Warthin tumor (WT). This systematic review and meta-analysis evaluated the accuracy of FNAC in the diagnosis of WT in the parotid gland and WT growth rate. For determination of FNAC accuracy, 17 studies, encompassing 1710 cases, were included. Pulled random model estimates of sensitivity, specificity, PPV, and NPV were 93.7% (95%CI: 92.1, 95.3), 97.9% (95%CI: 97, 98.9), 93.3% (95%CI: 91.5, 95.1), and 97.4% (95%CI: 96.4, 98.4), respectively. FNAC is highly reliable for the diagnosis of WT of the parotid. The high PPV value suggests that patients with a cytological diagnosis of WT of the parotid may be assigned to active surveillance.

Original languageEnglish
Pages (from-to)2277-2287
Number of pages11
JournalHead and Neck
Issue number10
StatePublished - Oct 2022

Bibliographical note

Publisher Copyright:
© 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.


  • Warthin tumor
  • diagnosis
  • fine-needle aspiration
  • parotid gland


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