Cytokinetic abscission is an acute G1 event

Ofir Gershony, Tal Péer, Meirav Noach-Hirsh, Natalie Elia, Amit Tzur

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Animal cell division ends with the cutting of the microtubule and membrane intercellular bridge connecting the 2 daughter cells. This process, known as cytokinetic abscission (abscission), is widely regarded as the last step of cytokinesis, i.e., the last step of the cell cycle. Major breakthroughs have been recently achieved, illuminating mechanistic aspects of abscission; however, the timing of abscission with respect to the mammalian cell cycle remains unclear. In this study, we carefully measured the onset and progression of abscission in dividing cells expressing a G1 reporter. We conclude that abscission commences long after cells enter the G1 phase. Affiliating abscission with G1 is beyond semantics since it essentially postulates that the last step of the cell cycle is regulated in, and probably by, the following cycle.

Original languageEnglish
Pages (from-to)3436-3441
Number of pages6
JournalCell Cycle
Issue number21
StatePublished - 1 Nov 2014

Bibliographical note

Funding Information:
Funding by the following foundations is gratefully acknowledged: Israeli Centers of Research Excellence (I-CORE), Gene Regulation in Complex Human Disease, Center no. 41/11 (AT), Israel Cancer Association grant no. 20120067 (AT), Israeli Science Foundation (ISF) grant no. 455/13 (NE), United States-Israel Binational Science Foundation (BSF) grant no. 2011309 (NE), and Marie Curie Integration grant (CIG) (NE).


  • APC/C
  • Abscission
  • Aurora
  • CHMP
  • Cell cycle
  • Cell division
  • Cep55
  • Constriction site
  • Cytokinesis
  • Gas2l3
  • Mitosis
  • Plk1
  • Spastin


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