Cyclosporine A-induced gingival hyperplasia pemphigus vulgaris: Literature review and report of a case

Orit Oettinger-Barak, Eli E. Machtei, Micha Peled, Shlomi Barak, Imad Abu L-Naaj, Dov Laufer

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Gingival hyperplasia appears in 8% to 85% of patients treated with cyclosporine. Most studies show an association between oral hygiene status and the prevalence and severity of this gingival overgrowth. Thus, besides attempting to substitute this drug with another whenever possible, treatment usually involves maintenance of strict oral hygiene coupled with scaling and root planing and removal of iatrogenic factors. Sometimes a second treatment phase involving periodontal surgery is necessary. Cyclosporine-induced gingival overgrowth has been mainly described in post-organ transplant patients. The present case describes, for the first time, a severe form of cyclosporine-induced gingival overgrowth arising in a 15 year-old male with pemphigus vulgaris. Periodontal treatment included oral hygiene and scaling and root planing under local anesthesia. There was a significant reduction in gingival enlargement, as well as a reduction in plaque levels and inflammation. Cessation of drug administration, combined with continuous periodontal treatment, brought further improvement. This successful conservative treatment of cyclosporine-induced gingival overgrowth in a pemphigus vulgaris patient suggests that early diagnosis and comprehensive treatment of these lesions may yield good response and reduce the need for periodontal surgery.

Original languageEnglish
Pages (from-to)650-656
Number of pages7
JournalJournal of Periodontology
Issue number4
StatePublished - Apr 2000
Externally publishedYes


  • Cyclosporine/adverse effects
  • Gingival hyperplasia/etiology
  • Pemphigus vulgaris
  • Planing
  • Scaling
  • Tooth root


Dive into the research topics of 'Cyclosporine A-induced gingival hyperplasia pemphigus vulgaris: Literature review and report of a case'. Together they form a unique fingerprint.

Cite this