Cycling State that Can Lead to Glassy Dynamics in Intracellular Transport

Monika Scholz, Stanislav Burov, Kimberly L. Weirich, Björn J. Scholz, S. M. Ali Tabei, Margaret L. Gardel, Aaron R. Dinner

Research output: Contribution to conferencePaperpeer-review


Power-law dwell times have been observed for molecular motors in living cells, but the origins of these trapped states are not known. We introduce a minimal model of motors moving on a two-dimensional network of filaments, and simulations of its dynamics exhibit statistics comparable to those observed experimentally. Analysis of the model trajectories, as well as experimental particle tracking data, reveals a state in which motors cycle unproductively at junctions of three or more filaments. We formulate a master equation for these junction dynamics and show that the time required to escape from this vortexlike state can account for the power-law dwell times. We identify trends in the dynamics with the motor valency for further experimental validation. We demonstrate that these trends exist in individual trajectories of myosin II on an actin network. We discuss how cells could regulate intracellular transport and, in turn, biological function by controlling their cytoskeletal network structures locally.
Original languageEnglish
StatePublished - 2016
EventPhysics of Soft and Biological Matter - Cambridge, United Kingdom
Duration: 6 Apr 20168 Apr 2016


ConferencePhysics of Soft and Biological Matter
Country/TerritoryUnited Kingdom


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  • Conference Contributed

    Borow, S. (Invited speaker)

    6 Apr 20168 Apr 2016

    Activity: Talk or presentationInvited talk

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