TY - JOUR
T1 - Current and future treatment of hepatocellular carcinoma
T2 - An updated comprehensive review
AU - Daher, Saleh
AU - Massarwa, Muhammad
AU - Benson, Ariel A.
AU - Khoury, Tawfik
N1 - Publisher Copyright:
© 2018 Authors.
PY - 2018/3/28
Y1 - 2018/3/28
N2 - Hepatocellular carcinoma (HCC) is among the leading causes of cancer-related mortality. The principal treatment is surgical resection or liver transplantation, depending on whether the patient is a suitable transplant candidate. However, in most patients with HCC the diagnosis is often late, thereby exclud-ing the patients from definitive surgical resection. Medical treatment includes sorafenib, which is the most commonly used systemic therapy; although, it has been shown to only minimally impact patient survival by several months. Chemotherapy and radiotherapy are generally ineffective. Due to the poor prognosis of patients with HCC, newer treatments are needed with several being in development, either in pre-clinical or clinical studies. In this review article, we provide an update on the current and future medical and surgical management of HCC.
AB - Hepatocellular carcinoma (HCC) is among the leading causes of cancer-related mortality. The principal treatment is surgical resection or liver transplantation, depending on whether the patient is a suitable transplant candidate. However, in most patients with HCC the diagnosis is often late, thereby exclud-ing the patients from definitive surgical resection. Medical treatment includes sorafenib, which is the most commonly used systemic therapy; although, it has been shown to only minimally impact patient survival by several months. Chemotherapy and radiotherapy are generally ineffective. Due to the poor prognosis of patients with HCC, newer treatments are needed with several being in development, either in pre-clinical or clinical studies. In this review article, we provide an update on the current and future medical and surgical management of HCC.
KW - HCC
KW - Mortality
KW - Sorafenib
KW - Treatments
UR - http://www.scopus.com/inward/record.url?scp=85052619713&partnerID=8YFLogxK
U2 - 10.14218/JCTH.2017.00031
DO - 10.14218/JCTH.2017.00031
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C2 - 29607307
AN - SCOPUS:85052619713
SN - 2225-0719
VL - 6
SP - 69
EP - 78
JO - Journal of Clinical and Translational Hepatology
JF - Journal of Clinical and Translational Hepatology
IS - 1
ER -
