TY - JOUR
T1 - CsF-mediated reaction of diazo compounds with 3-nitroindoles
T2 - access to cyano- and phosphonylpyrazolo[4,3-b]indoles
AU - Kumar, Sandeep
AU - Gupta, Ashis Kumar
AU - Vaishanv, Narendra Kumar
AU - Kant, Ruchir
AU - Mohanan, Kishor
N1 - Publisher Copyright:
© 2024 The Royal Society of Chemistry.
PY - 2024/9/26
Y1 - 2024/9/26
N2 - A CsF-promoted synthesis of cyanopyrazolo[4,3-b]indoles via a [3+2] cycloaddition reaction of diazoacetonitrile with N-substituted 3-nitroindoles and subsequent elimination of the nitro group has been devised. This protocol delivers diverse cyano-containing pyrazole-fused indoles in good to excellent yields under mild conditions. Besides diazoacetonitrile, the Seyferth-Gilbert reagent (SGR) readily participated in this reaction to provide facile access to phosphonylated pyrazolo[4,3-b]indoles.
AB - A CsF-promoted synthesis of cyanopyrazolo[4,3-b]indoles via a [3+2] cycloaddition reaction of diazoacetonitrile with N-substituted 3-nitroindoles and subsequent elimination of the nitro group has been devised. This protocol delivers diverse cyano-containing pyrazole-fused indoles in good to excellent yields under mild conditions. Besides diazoacetonitrile, the Seyferth-Gilbert reagent (SGR) readily participated in this reaction to provide facile access to phosphonylated pyrazolo[4,3-b]indoles.
UR - http://www.scopus.com/inward/record.url?scp=85205791715&partnerID=8YFLogxK
U2 - 10.1039/d4nj03266g
DO - 10.1039/d4nj03266g
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AN - SCOPUS:85205791715
SN - 1144-0546
VL - 48
SP - 17670
EP - 17675
JO - New Journal of Chemistry
JF - New Journal of Chemistry
IS - 40
ER -