Crystalline paclitaxel coated DES with bioactive protective layer development

Shady Farah, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Drug eluting stents (DES) based on polymeric-carriers currently lead the market, however, reports on clinical complications encourage the development of safer and more effective DES. We recently reported on carrier-free DES based on rapamycin crystalline coating as a potential therapeutic solution. Here, we report for the first time surface crystallization of paclitaxel (PT) onto metallic stents. The physicochemical principles of crystallization and key process parameters were extensively studied for fabrication of controllable and homogeneous crystalline coatings on stent scaffolds. Stents loaded with nearly 100 μg PT were chosen as a potential therapeutic device with a multilayer coating of 4–7 μm thickness. In vitro PT release from these coated stents shows constant release for at least 28 days with 10% cumulatively released. The effect of fast dissolving top coating on the physical stability of the coated stent was determined. The top coating enhances the mechanical stability of the crystalline coating during deployment and expansion simulations. Also, incorporating PT in the protective top coating for developing bioactive top coating for multilayer controlled release purpose was intensively studied. This process has wide applications that can be further implemented for other drugs for effective local drug delivery from implantable medical devices.

Original languageEnglish
Pages (from-to)107-117
Number of pages11
JournalJournal of Controlled Release
Volume271
DOIs
StatePublished - 10 Feb 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V.

Funding

This work was supported in part by a grant from the Israel Science Foundation (ISF) (No. 1051/12 ). Council for Higher Education-Israel, acknowledged for providing fellowship to Shady Farah. We should like to thank the Unit for Nanoscopic Characterization of the Hebrew University of Jerusalem for performing the XRD (Dr. Vladimir Uvarov) analysis. Appendix A This work was supported in part by a grant from the Israel Science Foundation (ISF) (No. 1051/12). Council for Higher Education-Israel, acknowledged for providing fellowship to Shady Farah. We should like to thank the Unit for Nanoscopic Characterization of the Hebrew University of Jerusalem for performing the XRD (Dr. Vladimir Uvarov) analysis.

FundersFunder number
Council for Higher Education-Israel
Hebrew University of Jerusalem
Israel Science Foundation1051/12

    Keywords

    • Bioactive coating
    • Controlled multilayer-release
    • Crystallization
    • Drug eluting stents
    • Hyaluronic acid
    • Paclitaxel

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