COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022

Limor Kliker; Neta Zuckerman; Nofar Atari; Noam Barda; Mayan Gilboa; Ital Nemet; Bayan Abd Elkader; Ilana S. Fratty; Hanaa Jaber; Ella Mendelson; Sharon Alroy-Preis; Yitshak Kreiss; Gili Regev-Yochay; Michal Mandelboim

doi:10.2807/1560-7917.ES.2022.27.30.2200559

COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022

Limor Kliker, Neta Zuckerman, Nofar Atari, Noam Barda, Mayan Gilboa, Ital Nemet, Bayan Abd Elkader, Ilana S. Fratty, Hanaa Jaber, Ella Mendelson, Sharon Alroy-Preis, Yitshak Kreiss, Gili Regev-Yochay, Michal Mandelboim

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

This work evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.4 and BA.5) in healthcare workers who had breakthrough BA.1 infection. Omicron breakthrough infection in individuals vaccinated three or four times before infection resulted in increased neutralising antibodies against the WT virus. The fourth vaccine dose did not further improve the neutralising efficiency over the third dose against all Omicron variants, especially BA.4 and BA.5. An Omicron-specific vaccine may be indicated.

Original language	English
Journal	Eurosurveillance
Volume	27
Issue number	30
DOIs	https://doi.org/10.2807/1560-7917.ES.2022.27.30.2200559
State	Published - 28 Jul 2022
Externally published	Yes

Bibliographical note

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© 2022 European Centre for Disease Prevention and Control (ECDC). All rights reserved.

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Kliker, L., Zuckerman, N., Atari, N., Barda, N., Gilboa, M., Nemet, I., Elkader, B. A., Fratty, I. S., Jaber, H., Mendelson, E., Alroy-Preis, S., Kreiss, Y., Regev-Yochay, G., & Mandelboim, M. (2022). COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022. Eurosurveillance, 27(30). https://doi.org/10.2807/1560-7917.ES.2022.27.30.2200559

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title = "COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022",

abstract = "This work evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.4 and BA.5) in healthcare workers who had breakthrough BA.1 infection. Omicron breakthrough infection in individuals vaccinated three or four times before infection resulted in increased neutralising antibodies against the WT virus. The fourth vaccine dose did not further improve the neutralising efficiency over the third dose against all Omicron variants, especially BA.4 and BA.5. An Omicron-specific vaccine may be indicated.",

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Kliker, L, Zuckerman, N, Atari, N, Barda, N, Gilboa, M, Nemet, I, Elkader, BA, Fratty, IS, Jaber, H, Mendelson, E, Alroy-Preis, S, Kreiss, Y, Regev-Yochay, G & Mandelboim, M 2022, 'COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022', Eurosurveillance, vol. 27, no. 30. https://doi.org/10.2807/1560-7917.ES.2022.27.30.2200559

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AU - Kliker, Limor

AU - Zuckerman, Neta

AU - Atari, Nofar

AU - Barda, Noam

AU - Gilboa, Mayan

AU - Nemet, Ital

AU - Elkader, Bayan Abd

AU - Fratty, Ilana S.

AU - Jaber, Hanaa

AU - Mendelson, Ella

AU - Alroy-Preis, Sharon

AU - Kreiss, Yitshak

AU - Regev-Yochay, Gili

AU - Mandelboim, Michal

PY - 2022/7/28

Y1 - 2022/7/28

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COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022

Abstract

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