Covalently Functionalized Graphene with Molecularly Imprinted Polymers for Selective Adsorption and Electrochemical Detection of Chloramphenicol

Thi Nhat Thang Nguyen, Nam Thi Pham, Dai Hung Ngo, Subodh Kumar, Xuan Thang Cao

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In this report, we have presented a novel route to attach molecularly imprinted polymers (MIPs) on the surface of reduced graphene oxide (rGO) through covalent bonding. First, the surface of rGO was modified with maleic anhydride (MA) via a Diels-Alder reaction using a deep eutectic solvent (DES). Next, 3-propyl-1-vinylimidazolium molecular units were anchored and polymerized in the presence of ethylene glycol dimethacrylate (EGDMA) using chloramphenicol (CAP) as the template. Primarily, we investigated the effect of the molar ratio of individual precursors on the adsorption capacity of synthesized materials and accordingly fabricated the electrochemical sensor for CAP detection. Electrochemical results evidenced that the covalent bonding of MIP units enhanced the sensitivity of the respective sensor toward CAP in water as well as in real honey samples with high selectivity, stability, and reproducibility. This synthesis strategy involves the covalent binding of MIP on rGO materials via click chemisty under sonication power excluding harmful solvents and energy-intensive processes and thus could be a motivation for developing future electrochemical sensors through similar “green” routes.

Original languageEnglish
Pages (from-to)25385-25391
Number of pages7
JournalACS Omega
Volume8
Issue number28
DOIs
StatePublished - 18 Jul 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 The Authors. Published by American Chemical Society.

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