TY - JOUR
T1 - Corticosteroids stimulate hepatitis B virus DNA, mRNA and protein production in a stable expression system
AU - Tur-Kaspa, Ran
AU - Laub, Orgad
PY - 1990/7
Y1 - 1990/7
N2 - The effect of corticosteroids (Dexamethasone) on hepatitis B virus was investigated in human hepatoblastoma cells stable transfected with recombinant HBV DNA. Dexamethasone was found to cause elevation of HBsAg, HBeAg and viral DNA production. HBV poly(A)+ RNA was significantly increased in cells treated with Dexamethasone. Furthermore, pulse labelled nuclear HBV RNA was also stimulated by Dexamethasone. These findings, suggest that corticosteroids enhance expression of viral gene products by stimulating HBV transcription.
AB - The effect of corticosteroids (Dexamethasone) on hepatitis B virus was investigated in human hepatoblastoma cells stable transfected with recombinant HBV DNA. Dexamethasone was found to cause elevation of HBsAg, HBeAg and viral DNA production. HBV poly(A)+ RNA was significantly increased in cells treated with Dexamethasone. Furthermore, pulse labelled nuclear HBV RNA was also stimulated by Dexamethasone. These findings, suggest that corticosteroids enhance expression of viral gene products by stimulating HBV transcription.
UR - http://www.scopus.com/inward/record.url?scp=0025004772&partnerID=8YFLogxK
U2 - 10.1016/0168-8278(90)90268-v
DO - 10.1016/0168-8278(90)90268-v
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C2 - 2168915
AN - SCOPUS:0025004772
SN - 0168-8278
VL - 11
SP - 34
EP - 36
JO - Journal of Hepatology
JF - Journal of Hepatology
IS - 1
ER -
