TY - JOUR
T1 - Cortical responses elicited by photovoltaic subretinal prostheses exhibit similarities to visually evoked potentials.,
AU - Mandel, Yossi
AU - Goetz, Georges
AU - Lavinsky, Daniel
AU - Huie, Philip
AU - Mathieson, Keith
AU - Wang, Lele
AU - Kamins, Theodore
AU - Galambos, Ludwig
AU - Manivanh, Richard
AU - Harris, James
AU - Palanker, Daniel
PY - 2013
Y1 - 2013
N2 - We have previously developed a wireless photovoltaic retinal prosthesis, in which camera-captured images are projected onto the retina using pulsed near-IR light. Each pixel in the subretinal implant directly converts pulsed light into local electric current to stimulate the nearby inner retinal neurons. Here we report that implants having pixel sizes of 280, 140 and 70 $\mu$m implanted in the subretinal space in rats with normal and degenerate retina elicit robust cortical responses upon stimulation with pulsed near-IR light. Implant-induced eVEP has shorter latency than visible light-induced VEP, its amplitude increases with peak irradiance and pulse duration, and decreases with frequency in the range of 2-20 Hz, similar to the visible light response. Modular design of the arrays allows scalability to a large number of pixels, and combined with the ease of implantation, offers a promising approach to restoration of sight in patients blinded by retinal degenerative diseases.,
AB - We have previously developed a wireless photovoltaic retinal prosthesis, in which camera-captured images are projected onto the retina using pulsed near-IR light. Each pixel in the subretinal implant directly converts pulsed light into local electric current to stimulate the nearby inner retinal neurons. Here we report that implants having pixel sizes of 280, 140 and 70 $\mu$m implanted in the subretinal space in rats with normal and degenerate retina elicit robust cortical responses upon stimulation with pulsed near-IR light. Implant-induced eVEP has shorter latency than visible light-induced VEP, its amplitude increases with peak irradiance and pulse duration, and decreases with frequency in the range of 2-20 Hz, similar to the visible light response. Modular design of the arrays allows scalability to a large number of pixels, and combined with the ease of implantation, offers a promising approach to restoration of sight in patients blinded by retinal degenerative diseases.,
UR - http://www.nature.com/ncomms/2013/130618/ncomms2980/full/ncomms2980.html?WT.ec\_id=NCOMMS-20130619,
UR - http://scholar.google.com/scholar?num=3&hl=en&lr=&q=allintitle%3A%20Cortical%20responses%20elicited%20by%20photovoltaic%20subretinal%20prostheses%20exhibit%20similarities%20to%20visually%20evoked%20potentials.%2C%20author%3AYossi%20OR%20author%3AMandel%20OR%20author%3AGeorges%20OR%20author%3AGoetz%20OR%20author%3ADaniel%20OR%20author%3ALavinsky%20OR%20author%3APhilip%20OR%20author%3AHuie%20OR%20author%3AKeith%20OR%20author%3AMathieson%20OR%20author%3ALele%20OR%20author%3AWang%20OR%20author%3ATheodore%20OR%20author%3AKamins%20OR%20author%3ALudwig%20OR%20author%3AGalambos%20OR%20author%3ARichard%20OR%20author%3AManivanh%20OR%20author%3AJames%20OR%20author%3AHarris%20OR%20author%3ADaniel%20OR%20author%3APalanker&as_ylo=2013&as_yhi=&btnG=Search&as_vis=0
M3 - Article
VL - 4
SP - 1980
JO - Nature Communications,
JF - Nature Communications,
ER -
