Correlation of maternal serum and amniotic fluid leptin and insulin levels with neonatal birth weight

Yuri Perlitz, Sofia Glezer-Soltzman, Aviva Peleg, Nesia Lang, Benny Almog, Moshe Ben-Ami

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Numerous studies correlated maternal serum and fetal cord leptin levels in pregnancy with new born weight (NBW) and maternal body mass index (BMI). However, there are only a few published studies concerning amniotic fluid leptin and its possible relationship to fetal growth and NBW. Objective: To correlate leptin and insulin in amniotic fluid and maternal serum collected at 16-20 gestational weeks to NBW. Methods: This was an observational study in which maternal serum leptin, insulin, and amniotic fluid leptin and insulin, studied from 70 healthy pregnant women undergoing amniocentesis for karyotyping, at 16-20 weeks' gestation. NBW was correlated with maternal BMI and leptin and insulin levels in maternal serum and amniotic fluid. Results: Maternal serum leptin was detected as the best predictor of NBW. Squared correlation coefficient, r2 = 0.09, was statistically significant (P < .01). Maternal BMI correlated significantly with serum levels of insulin and leptin r2= 0.16 and 0.27 respectively, P < .01. Conclusions: In normal pregnancies, amniotic fluid leptin correlates partially with NBW. Maternal serum leptin correlates significantly with NBW.

Original languageHebrew
Pages (from-to)420-423
Number of pages4
Issue number7
StatePublished - Jul 2009
Externally publishedYes


  • Insulin
  • Leptin
  • Neonatal birth weight
  • Pregnancy


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