Correlation of cytokine secretion by mononuclear cells of Alzheimer patients and their disease stage

M. Huberman, F. Shalit, I. Roth-Deri, B. Gutman, C. Brodie, E. Kott, B. Sredni

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    105 Scopus citations

    Abstract

    Cytokine secretion by human mononuclear cells (MNC) was investigated in age-matched controls and in patients with Alzheimer's disease (AD). AD patients were divided into two study groups: 'mild' and 'moderately severe'. A significant increase in interleukin-2 (IL-2) and gamma interferon (IFN-γ) secretion was found in AD patients in the moderately severe stage of the disease, whereas in the mild stage of the disease there was a significant decrease in interleukin-3 activity (IL-3) and tumor necrosis factor (TNF) levels. No significant differences were found in the level of production of interleukin-1 (IL-1β). Our results demonstrate the existence of defective immune functions in AD patients which are correlated with the clinical condition of these patients.

    Original languageEnglish
    Pages (from-to)147-152
    Number of pages6
    JournalJournal of Neuroimmunology
    Volume52
    Issue number2
    DOIs
    StatePublished - Jul 1994

    Bibliographical note

    Funding Information:
    This work was partly supported by the Frieda Stoll-man Cancer Memorial Fund and partly by the Israel Research Cancer Fund.

    Funding

    This work was partly supported by the Frieda Stoll-man Cancer Memorial Fund and partly by the Israel Research Cancer Fund.

    FundersFunder number
    Frieda Stoll-man Cancer Memorial Fund
    Israel Cancer Research Fund

      Keywords

      • Alzheimer's disease
      • Interferon-γ
      • Interleukin-1
      • Interleukin-2
      • Interleukin-3
      • Tumor necrosis factor

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