Abstract
Cytokine secretion by human mononuclear cells (MNC) was investigated in age-matched controls and in patients with Alzheimer's disease (AD). AD patients were divided into two study groups: 'mild' and 'moderately severe'. A significant increase in interleukin-2 (IL-2) and gamma interferon (IFN-γ) secretion was found in AD patients in the moderately severe stage of the disease, whereas in the mild stage of the disease there was a significant decrease in interleukin-3 activity (IL-3) and tumor necrosis factor (TNF) levels. No significant differences were found in the level of production of interleukin-1 (IL-1β). Our results demonstrate the existence of defective immune functions in AD patients which are correlated with the clinical condition of these patients.
| Original language | English |
|---|---|
| Pages (from-to) | 147-152 |
| Number of pages | 6 |
| Journal | Journal of Neuroimmunology |
| Volume | 52 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jul 1994 |
Bibliographical note
Funding Information:This work was partly supported by the Frieda Stoll-man Cancer Memorial Fund and partly by the Israel Research Cancer Fund.
Funding
This work was partly supported by the Frieda Stoll-man Cancer Memorial Fund and partly by the Israel Research Cancer Fund.
| Funders | Funder number |
|---|---|
| Frieda Stoll-man Cancer Memorial Fund | |
| Israel Cancer Research Fund |
Keywords
- Alzheimer's disease
- Interferon-γ
- Interleukin-1
- Interleukin-2
- Interleukin-3
- Tumor necrosis factor
