Correlated mutations at gp120 positions 322 and 440: Implications for gp120 structure

Osnat Rosen, Avraham O. Samson, Jacob Anglister

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Analysis of V3 and C4 sequences of HIV-1 reveals correlated mutations at gp120 positions 322 and 440, and a very strong preference for a positively charged residue at position 440 when position 322 is negatively charged. This observation suggests that these two residues are close to each other and interact electrostatically in R5 viruses. This interaction was used to model V3 in the context of gp120 using NMR data for the V3 loop and the crystal structure of the gp120-core. The interaction between residues 322 and 440 may serve as part of the molecular switch for HIV-1 phenotype conversion.

Original languageEnglish
Pages (from-to)1066-1070
Number of pages5
JournalProteins: Structure, Function and Genetics
Volume71
Issue number3
DOIs
StatePublished - 15 May 2008
Externally publishedYes

Keywords

  • Correlated mutation
  • HIV
  • Structure
  • V3
  • gp120

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