Core/Shell Iron Oxide@Gold nanoparticles for dual-modal CT/MRI imaging

Oshra Betzer; Menachem Motiei; Tamar Dreifuss; Tamar Sadan; Noam Omer; Tamar Blumenfeld-Katzir; Zhuang Liu; Noam Ben-Eliezer; Rachela Popovtzer

doi:10.1117/12.2548430

Core/Shell Iron Oxide@Gold nanoparticles for dual-modal CT/MRI imaging

Oshra Betzer, Menachem Motiei, Tamar Dreifuss, Tamar Sadan, Noam Omer, Tamar Blumenfeld-Katzir, Zhuang Liu, Noam Ben-Eliezer, Rachela Popovtzer

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

7 Scopus citations

Abstract

Multimodal imaging, integrating different imaging modalities, is emerging as a promising strategy for improving both preclinical and clinical imaging. Computed tomography (CT) and magnetic resonance imaging (MRI) are among the widely clinically-used imaging techniques. These imaging modalities are used for disease diagnosis and screening, each providing different and complementary information about the patient and the disease state. Nanoparticles are considered promising contrast agents for in vivo imaging applications, providing improved imaging and targeting capabilities compared to the commonly used contrast compounds. In this project, we present the development of a novel hybrid nanostructure, comprising of iron oxide core and gold shell nanoparticle for dual model CT and MRI imaging. The hybrid structures presented herein have potential to serve as a unique platform for precision imaging.

Original language	English
Title of host publication	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII
Editors	Dror Fixler, Ewa M. Goldys, Sebastian Wachsmann-Hogiu
Publisher	SPIE
ISBN (Electronic)	9781510632714
DOIs	https://doi.org/10.1117/12.2548430
State	Published - 2020
Event	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII 2020 - San Francisco, United States Duration: 2 Feb 2020 → 3 Feb 2020

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	11254
ISSN (Print)	1605-7422

Conference

Conference	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII 2020
Country/Territory	United States
City	San Francisco
Period	2/02/20 → 3/02/20

Bibliographical note

Publisher Copyright:
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

Funding

This work was partially supported by the European Union Horizon 2020- research and innovation program under grant agreement #761031, by the Council for Higher Education Postdoctoral Fellowship for Outstanding Woman in Science, and by the Ministry of Science Technology & Space Postdoctoral scholarship, granted to Oshra Betzer. This work was partially supported by the European Union Horizon 2020-research and innovation program under grant agreement #761031, by the Council for Higher Education Postdoctoral Fellowship for Outstanding Woman in Science, and by the Ministry of Science Technology & Space Postdoctoral scholarship, granted to Oshra Betzer.

Funders	Funder number
European Union Horizon 2020- research and innovation program
European Union Horizon 2020-research and innovation program	761031
Ministry of Science Technology
Ministry of Science and Technology, Taiwan
Council for Higher Education

Keywords

CT
Core-shell
Gold nanoparticles
Iron Oxide nanoparticles
MRI
Multimodal imaging

Access to Document

10.1117/12.2548430

Cite this

Betzer, O., Motiei, M., Dreifuss, T., Sadan, T., Omer, N., Blumenfeld-Katzir, T., Liu, Z., Ben-Eliezer, N., & Popovtzer, R. (2020). Core/Shell Iron Oxide@Gold nanoparticles for dual-modal CT/MRI imaging. In D. Fixler, E. M. Goldys, & S. Wachsmann-Hogiu (Eds.), Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII Article 112541F (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11254). SPIE. https://doi.org/10.1117/12.2548430

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abstract = "Multimodal imaging, integrating different imaging modalities, is emerging as a promising strategy for improving both preclinical and clinical imaging. Computed tomography (CT) and magnetic resonance imaging (MRI) are among the widely clinically-used imaging techniques. These imaging modalities are used for disease diagnosis and screening, each providing different and complementary information about the patient and the disease state. Nanoparticles are considered promising contrast agents for in vivo imaging applications, providing improved imaging and targeting capabilities compared to the commonly used contrast compounds. In this project, we present the development of a novel hybrid nanostructure, comprising of iron oxide core and gold shell nanoparticle for dual model CT and MRI imaging. The hybrid structures presented herein have potential to serve as a unique platform for precision imaging.",

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Betzer, O, Motiei, M, Dreifuss, T, Sadan, T, Omer, N, Blumenfeld-Katzir, T, Liu, Z, Ben-Eliezer, N & Popovtzer, R 2020, Core/Shell Iron Oxide@Gold nanoparticles for dual-modal CT/MRI imaging. in D Fixler, EM Goldys & S Wachsmann-Hogiu (eds), Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII., 112541F, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11254, SPIE, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII 2020, San Francisco, United States, 2/02/20. https://doi.org/10.1117/12.2548430

Core/Shell Iron Oxide@Gold nanoparticles for dual-modal CT/MRI imaging. / Betzer, Oshra; Motiei, Menachem; Dreifuss, Tamar et al.
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII. ed. / Dror Fixler; Ewa M. Goldys; Sebastian Wachsmann-Hogiu. SPIE, 2020. 112541F (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11254).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Blumenfeld-Katzir, Tamar

AU - Liu, Zhuang

AU - Ben-Eliezer, Noam

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Betzer O, Motiei M, Dreifuss T, Sadan T, Omer N, Blumenfeld-Katzir T et al. Core/Shell Iron Oxide@Gold nanoparticles for dual-modal CT/MRI imaging. In Fixler D, Goldys EM, Wachsmann-Hogiu S, editors, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII. SPIE. 2020. 112541F. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2548430

Core/Shell Iron Oxide@Gold nanoparticles for dual-modal CT/MRI imaging

Abstract

Publication series

Conference

Bibliographical note

Funding

Keywords

Access to Document

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