Core promoter functions in the regulation of gene expression of drosophila dorsal target genes

Yonathan Zehavi, Olga Kuznetsov, Avital Ovadia-Shochat, Tamar Juven-Gershon

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Background: The Dorsal transcription factor regulates the dorsal-ventral developmental gene regulatory network by binding to enhancers. Results: The core promoters of multiple Dorsal target genes are evolutionarily conserved and functionally dependent on specific elements. Conclusion: The core promoter composition is an important determinant of the transcriptional outcome. Significance: Transcriptional regulation results from an interplay between enhancers and core promoter composition.

Original languageEnglish
Pages (from-to)11993-12004
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number17
DOIs
StatePublished - 25 Apr 2014

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