Abstract
Pharmaceutical grade d,l-lactic acid, which is rather an economic source in comparison to lactide monomer, was utilized for synthesis of a series of copolymers with sebacic acid. Polymers were characterized by GPC, FTIR, NMR and DSC techniques, and formulated into blank and methotrexate (MTX) loaded microspheres by emulsion-solvent evaporation method. In vitro degradation of blank microspheres was studied by FTIR, GPC and SEM analysis. MTX loaded microspheres showed the encapsulation efficiency of 44-64% and were in the size range of 40-60 μm. These were used to study the release profile of the encapsulated drug. The release was found to be affected by the pH and buffer concentration of the release medium which was in turn revealed by solubility studies of MTX. The overall study demonstrates significance of drug as well as polymer properties on release. Biocompatibility of polymer was evaluated by injecting microspheres subcutaneously into Sprague-Dawley (SD) rat and no local histopathological abnormalities were found.
| Original language | English |
|---|---|
| Pages (from-to) | 277-286 |
| Number of pages | 10 |
| Journal | European Journal of Pharmaceutics and Biopharmaceutics |
| Volume | 64 |
| Issue number | 3 |
| DOIs | |
| State | Published - Nov 2006 |
| Externally published | Yes |
Bibliographical note
Funding Information:Authors S.M. and J.P.J. are thankful for NIPER fellowship. Partial research support from Third World of Academy of Science (TWAS) and start-up fund from NIPER are duly acknowledged to carry out the research work.
Funding
Authors S.M. and J.P.J. are thankful for NIPER fellowship. Partial research support from Third World of Academy of Science (TWAS) and start-up fund from NIPER are duly acknowledged to carry out the research work.
| Funders | Funder number |
|---|---|
| NIPER | |
| The World Academy of Sciences | |
| Bilim Akademisi |
Keywords
- Biocompatibility
- Biodegradable polymers
- Drug delivery
- Drug release kinetics
- Microspheres
- PLA-PSA
- Profile modeling