Abstract
Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects. In this review, we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy, emphasizing challenges in cancer treatments.
| Original language | English |
|---|---|
| Article number | 7 |
| Journal | Signal Transduction and Targeted Therapy |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Dec 2018 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2018, The Author(s).
Funding
Research fellowships from UGC (New Delhi, India) (S.S.) and CSIR (New Delhi, India) (A. K.M.) are gratefully acknowledged. We also acknowledge the Science and Engineering Research Board (Grant No: R&D/SERB/LT/SMST/16/17/06) (SERB) New Delhi for financial support. We also acknowledge the Council for Scientific and Industrial Research (Grant No. 02(0074)/12/EMR-II) (CSIR-UGC), New Delhi.
| Funders | Funder number |
|---|---|
| CSIR-UGC | |
| Council for Scientific and Industrial Research, South Africa | 02(0074)/12/EMR-II |
| Council of Scientific and Industrial Research, India | |
| University Grants Committee | |
| Science and Engineering Research Board | R&D/SERB/LT/SMST/16/17/06 |
