Controlled drug delivery vehicles for cancer treatment and their performance

Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar, Pralay Maiti

Research output: Contribution to journalReview articlepeer-review

1803 Scopus citations

Abstract

Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects. In this review, we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy, emphasizing challenges in cancer treatments.

Original languageEnglish
Article number7
JournalSignal Transduction and Targeted Therapy
Volume3
Issue number1
DOIs
StatePublished - 1 Dec 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018, The Author(s).

Funding

Research fellowships from UGC (New Delhi, India) (S.S.) and CSIR (New Delhi, India) (A. K.M.) are gratefully acknowledged. We also acknowledge the Science and Engineering Research Board (Grant No: R&D/SERB/LT/SMST/16/17/06) (SERB) New Delhi for financial support. We also acknowledge the Council for Scientific and Industrial Research (Grant No. 02(0074)/12/EMR-II) (CSIR-UGC), New Delhi.

FundersFunder number
CSIR-UGC
Council for Scientific and Industrial Research, South Africa02(0074)/12/EMR-II
Council of Scientific and Industrial Research, India
University Grants Committee
Science and Engineering Research BoardR&D/SERB/LT/SMST/16/17/06

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