Abstract
Patients with schizophrenia exhibit cognitive and sensory impairment, and object recognition deficits have been linked to sensory deficits. The "frame and fill" model of object recognition posits that low spatial frequency (LSF) information rapidly reaches the prefrontal cortex (PFC) and creates a general shape of an object that feeds back to the ventral temporal cortex to assist object recognition. Visual dysfunction findings in schizophrenia suggest a preferential loss of LSF information. This study used functional magnetic resonance imaging (fMRI) and resting state functional connectivity (RSFC) to investigate the contribution of visual deficits to impaired object "framing" circuitry in schizophrenia. Participants were shown object stimuli that were intact or contained only LSF or high spatial frequency (HSF) information. For controls, fMRI revealed preferential activation to LSF information in precuneus, superior temporal, and medial and dorsolateral PFC areas, whereas patients showed a preference for HSF information or no preference. RSFC revealed a lack of connectivity between early visual areas and PFC for patients. These results demonstrate impaired processing of LSF information during object recognition in schizophrenia, with patients instead displaying increased processing of HSF information. This is consistent with findings of a preference for local over global visual information in schizophrenia.
| Original language | English |
|---|---|
| Pages (from-to) | 1849-1858 |
| Number of pages | 10 |
| Journal | Cerebral Cortex |
| Volume | 23 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2013 |
Bibliographical note
Funding Information:This work was supported by the National Institutes of Health (RO1 MH084848 to P.D.B. and M.J.H., R21 MH084031 to M.J. H., and R37 MH049334 and P50 MH086385 to D.C.J.), and the scanner used in this study was funded in part by S10 RR022972 NCRR High End Instrumentation grant to Craig A. Branch, PhD) and the Graduate Center of the City University of New York (Doctoral Student Research Grant to D.J.C.
Funding
This work was supported by the National Institutes of Health (RO1 MH084848 to P.D.B. and M.J.H., R21 MH084031 to M.J. H., and R37 MH049334 and P50 MH086385 to D.C.J.), and the scanner used in this study was funded in part by S10 RR022972 NCRR High End Instrumentation grant to Craig A. Branch, PhD) and the Graduate Center of the City University of New York (Doctoral Student Research Grant to D.J.C.
| Funders | Funder number |
|---|---|
| National Institutes of Health | P50 MH086385, S10 RR022972, R21 MH084031, RO1 MH084848 |
| National Institute of Mental Health | R37MH049334 |
| National Center for Research Resources | |
| City University of New York |
Keywords
- cortical circuitry
- magnocellular
- object recognition
- schizophrenia
- visual