Construction of Enzyme Nanoreactors to Enable Tumor Microenvironment Modulation and Enhanced Cancer Treatment

Xiaowen Liu; Yu Hao; Rachela Popovtzer; Liangzhu Feng; Zhuang Liu

doi:10.1002/adhm.202001167

Construction of Enzyme Nanoreactors to Enable Tumor Microenvironment Modulation and Enhanced Cancer Treatment

Xiaowen Liu, Yu Hao, Rachela Popovtzer, Liangzhu Feng, Zhuang Liu

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Enzymes play pivotal roles in regulating and maintaining the normal functions of all living systems, and some of them are extensively employed for diagnosis and treatment of diverse diseases. More recently, several kinds of enzymes with unique catalytic activities have been found to be promising options to directly suppress tumor growth and/or augment the therapeutic efficacy of other treatments by modulating the hostile tumor microenvironment (TME), which is reported to negatively impair the therapeutic efficacy of different cancer treatments. In this review, first a summary is presented on the chemical approaches utilized for the construction of distinct enzyme nanoreactors with well-retained catalytic performance and reduced immunogenicity. Then, the utilization of such enzyme nanoreactors in attenuating tumor hypoxia, modulating extracellular matrix, and amplifying tumor oxidative stress is discussed in depth. Afterward, some perspectives are presented on the future development of such enzyme nanoreactors in TME modulation and enhanced cancer treatment.

Original language	English
Article number	2001167
Journal	Advanced healthcare materials
Volume	10
Issue number	5
DOIs	https://doi.org/10.1002/adhm.202001167
State	Published - 3 Mar 2021

Bibliographical note

Publisher Copyright:
© 2020 Wiley-VCH GmbH

Funding

X.L. and Y.H. contributed equally to this work. This work was partially supported by the National Natural Science Foundation of China (51802209, 81903546, 51761145041 and 21927803), the National Research Programs from Ministry of Science and Technology (MOST) of China (2016YFA0201200), the Natural Science Foundation of Jiangsu Province (BK20180848), the Jiangsu Social Development Project (BE2019658), the Collaborative Innovation Center of Suzhou Nano Science and Technology, and the 111 Program from the Ministry of Education of China.

Funders	Funder number
Jiangsu Social Development Project	BE2019658
National Natural Science Foundation of China	21927803, 51802209, 81903546, 51761145041
Ministry of Education of the People's Republic of China
Ministry of Science and Technology of the People's Republic of China	2016YFA0201200
Natural Science Foundation of Jiangsu Province	BK20180848
Collaborative Innovation Center of Suzhou Nano Science and Technology

Keywords

TME modulation
cancer treatment
enzyme nanoreactors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/adhm.202001167

Cite this

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abstract = "Enzymes play pivotal roles in regulating and maintaining the normal functions of all living systems, and some of them are extensively employed for diagnosis and treatment of diverse diseases. More recently, several kinds of enzymes with unique catalytic activities have been found to be promising options to directly suppress tumor growth and/or augment the therapeutic efficacy of other treatments by modulating the hostile tumor microenvironment (TME), which is reported to negatively impair the therapeutic efficacy of different cancer treatments. In this review, first a summary is presented on the chemical approaches utilized for the construction of distinct enzyme nanoreactors with well-retained catalytic performance and reduced immunogenicity. Then, the utilization of such enzyme nanoreactors in attenuating tumor hypoxia, modulating extracellular matrix, and amplifying tumor oxidative stress is discussed in depth. Afterward, some perspectives are presented on the future development of such enzyme nanoreactors in TME modulation and enhanced cancer treatment.",

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Construction of Enzyme Nanoreactors to Enable Tumor Microenvironment Modulation and Enhanced Cancer Treatment

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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