Constitutive knockout of interleukin-6 ameliorates memory deficits and entorhinal astrocytosis in the MRL/lpr mouse model of neuropsychiatric lupus

Keyphrases

• Interleukin-6 100%
• Memory Deficits 100%
• Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) 100%
• Astrocytosis 100%
• MRL Mouse 100%
• Constitutive Knockout 100%
• Entorhinal 100%
• KO Mice 22%
• Learning Impairment 11%
• Hippocampus 11%
• Astrocytes 11%
• Cerebrospinal Fluid 11%
• Lpr Mice 11%
• Microglia 11%
• Interleukin-6 Levels 11%
• Cortex 5%
• Serum Levels 5%
• Learning Development 5%
• Imaging Studies 5%
• Amygdala 5%
• Anxiety-like Behavior 5%
• Sucrose Preference 5%
• Quantitative PCR 5%
• Motivated Behavior 5%
• Cognitive-affective Processes 5%
• Depressive-like Behavior 5%
• Interleukin-17 (IL-17) 5%
• Monocyte Chemoattractant protein-1 (MCP-1) 5%
• Memory Performance 5%
• Object Recognition 5%
• Lupus 5%
• Glial Cells 5%
• Iba1 5%
• Inflammatory Genes 5%
• Neurobehavioral Deficits 5%
• Neuroinflammation 5%
• Behavioral Deficits 5%
• Learning Performance 5%
• Entorhinal Cortex 5%
• Systemic Autoimmunity 5%
• Protein Microarray 5%
• Immunofluorescent Staining 5%
• Behavioral Tests 5%
• Cognitive Memory 5%
• Emotional Burden 5%
• Preclinical Imaging 5%
• WT Mice 5%
• Novelty Preference 5%
• Serum interleukin-6 5%
• Cerebrospinal Fluid Samples 5%
• Memory Development 5%
• Cerebrospinal Fluid Analysis 5%
• Object Placement 5%
• Gfap 5%
• Cortical Regions 5%
• Equivalent Performance 5%
• Lupus Mice 5%

Neuroscience

• Interleukin 6 100%
• Lupus Erythematosus 100%
• Microglia 15%
• Behavior (Neuroscience) 10%
• Hippocampus 10%
• Astrocyte 10%
• Amygdala 5%
• Staining Technique 5%
• Interleukin 17 5%
• Entorhinal Cortex 5%
• Behavioral Test 5%
• Real-Time Polymerase Chain Reaction 5%
• Sucrose 5%
• Protein Microarray 5%
• Cortical Region 5%

Immunology and Microbiology

• Entorhinal Cortex 5%